| HPLC同时测定新健胃包芯片中5种蒽醌类成分的含量 |
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| 引用本文： | 李平,郑艳春,杨冬丽,张东阁,崔雅慧,闫春风,秦婷.HPLC同时测定新健胃包芯片中5种蒽醌类成分的含量[J].中国现代中药,2013,15(5):406-409. |
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| 作者姓名： | 李平 郑艳春 杨冬丽 张东阁 崔雅慧 闫春风 秦婷 |
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| 作者单位： | 颈复康药业集团有限公司，河北省中药新辅料工程技术研究中心,河北承德067000;颈复康药业集团有限公司，河北省中药新辅料工程技术研究中心,河北承德067000;颈复康药业集团有限公司，河北省中药新辅料工程技术研究中心,河北承德067000;颈复康药业集团有限公司，河北省中药新辅料工程技术研究中心,河北承德067000;颈复康药业集团有限公司，河北省中药新辅料工程技术研究中心,河北承德067000;颈复康药业集团有限公司，河北省中药新辅料工程技术研究中心,河北承德067000;颈复康药业集团有限公司，河北省中药新辅料工程技术研究中心,河北承德067000 |
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| 摘 要： | 目的:建立HPLC法测定新健胃包芯片中5种蒽醌类成分的含量。方法:色谱柱:Diamonsil C8柱,流动相:甲醇(A)-0.3%磷酸(B)梯度洗脱,柱温:25℃,流速:1.0mL·min-1,检测波长:430nm。结果:芦荟大黄素、大黄酸、大黄素、大黄酚、大黄素甲醚平均回收率(n=9)分别为99.5%,97.7%,105.4%,100.1%,106.1%,RSD值分别为1.15%,1.76%,1.79%,1.74%,1.93%;芦荟大黄素、大黄酸、大黄素、大黄酚、大黄素甲醚分别在进样量为0.041～0.205、0.041～0.202、0.049～0.245、0.097～0.484、0.042～0.212μg与峰面积呈良好线性关系。结论:该方法简便、灵敏、结果准确可靠,适用于该制剂中蒽醌类成分的质量控制。
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| 关 键 词： | 包芯片 芦荟大黄素 大黄酸 大黄素 大黄酚 大黄素甲醚 HPLC |
| 收稿时间： | 2012/9/16 0:00:00 |
Determination of Five Anthraquinone Components in Xin Jianwei Package Tablet by HPLC |
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| LI Ping,ZHENG Yan-chun,YANG Dong-li,ZHANG Dong-ge,CUI Ya-hui,YAN Chun-feng and QIN Ting.Determination of Five Anthraquinone Components in Xin Jianwei Package Tablet by HPLC[J].Modern Chinese Medicine,2013,15(5):406-409. |
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| Authors: | LI Ping ZHENG Yan-chun YANG Dong-li ZHANG Dong-ge CUI Ya-hui YAN Chun-feng and QIN Ting |
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| Institution: | Jingfukang Pharmaceutical Group Co.Ltd.,The New Excipients of Traditional Chinese Medicine Engineering Research Center of Hebei Province,Chengde 067000,China;Jingfukang Pharmaceutical Group Co.Ltd.,The New Excipients of Traditional Chinese Medicine Engineering Research Center of Hebei Province,Chengde 067000,China;Jingfukang Pharmaceutical Group Co.Ltd.,The New Excipients of Traditional Chinese Medicine Engineering Research Center of Hebei Province,Chengde 067000,China;Jingfukang Pharmaceutical Group Co.Ltd.,The New Excipients of Traditional Chinese Medicine Engineering Research Center of Hebei Province,Chengde 067000,China;Jingfukang Pharmaceutical Group Co.Ltd.,The New Excipients of Traditional Chinese Medicine Engineering Research Center of Hebei Province,Chengde 067000,China;Jingfukang Pharmaceutical Group Co.Ltd.,The New Excipients of Traditional Chinese Medicine Engineering Research Center of Hebei Province,Chengde 067000,China;Jingfukang Pharmaceutical Group Co.Ltd.,The New Excipients of Traditional Chinese Medicine Engineering Research Center of Hebei Province,Chengde 067000,China |
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| Abstract: | Objective： To establish a HPLC method for determining five anthraquinone components m Am Jianwei package tablet. Methods： Diamonsil Cs column was used with the mobile phase methanol （A） -0. 3% phosphate acid solution（B） , gradient elution, the flow rate was 1.0 mL. min- 1 and detection wavelength was set at 430 nm. Results： The average recoveries of aloe-emodin, rhein, emodin, chrysophanol and physcion were 99.5%, 97.7%, 105.4%, 100.1%, 106.1% respectively; RSD were 1.15%, 1.76%, 1.79%, 1.74%, 1.93% respectively. The linear range of them was 0. 041 - 0. 205, 0. 041 - 0. 202, 0. 049 - 0. 245, 0. 097 - 0. 484, 0. 042-0. 212 μg respectively. Conclusion： The method is simple, sensitive, accurate and can be used for the quality control of Xin Jianwei package Tablet. . |
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| Keywords: | Package tablet Aloe-emodin Rhein Emodin Chrysophanol Physcion HPLC |
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