PTTG基因及Ki67抗原在胃癌组织中的表达及意义

目的　探讨PTTG基因和Ki6 7在胃癌发生、发展中的作用及二者的相关性。方法　采用免疫组织化学SP法检测了4 0例胃癌患者胃组织中PTTG基因和Ki6 7的表达情况。结果　PTTG基因和Ki6 7在胃癌组织中的阳性表达率分别为72 .5 %和95 % ,均与胃癌的病理组织学分级、临床分期及淋巴结转移有关(P<0 .0 5 ) ,而与组织学类型无关(P>0 .0 5 )。PTTG基因和Ki6 7表达强度呈显著正相关(P<0 .0 5 )。结论　PTTG基因和Ki6 7在胃癌的发生、发展中有协同作用,可作为反映胃癌生物学行为的指标。

The expression and its significance of PTTG gene and Ki67 in gastric carcinoma

Objective To study the role of PTTG gene and Ki67 in the process of gastric carcinoma and their correlationship.Methods Immunohistochemical staining(SP)was used to examine the expression of PTTG gene and Ki67 in 40 cases of gastric carcinomas.Results The positive rate of PTTG gene and Ki67 were 72.5% and 95% in gastric carcinoma respectively.The expressions of them were related to histophathological grade,clinical stage and lymph node metastasis(P<0.05),but to histological type of gastric carcinoma(P>0.05).There was a positive correlation between the expressive intensity of PTTG gene and Ki67 (P<0.05).Conclusions The results suggest that PTTG gene and Ki67 play a cooperative role in the process of gastric carcinoma and may serve as a useful marker for assess ment of the biological behavior of gastric carcinoma.