放射生物学数学模型的研究进展

目的：放射生物学数学模型随着放射治疗的发展不断被提出,最早提出了L-Q模型和靶模型,由于靶模型形式较为复杂、参数较多,L-Q模型得到了广泛的应用。但是随着SRS、SBRT大剂量放疗的出现,越来越多的证据表明,L-Q模型在大剂量范围计算精度不高,尤其是从常规低剂量到大剂量。研究者提出了新的放射生物学数学模型。方法：本文按照模型被提出的时间顺序对L-Q模型、SH-MT模型、ML-Q模型、USC模型、gL-Q模型进行阐述。结果：ML-Q模型、USC模型、gL-Q模型与实验数据符合较好。结论 ：相比较而言,对于目前SRS、SBRT大剂量照射,USC模型和gL-Q模型可能更为适用,但USC模型和gL-Q模型的适用性和模型中的参数仍需进一步的确认。

The Advances of Mathematical Models in Radiobiology

Objective：With the development of radiation therapy, mathematical models in radiobiology have been proposed. L-Q model and target model were proposd firstly,bnt because the form of target model was complex, so L-Q model was more popular.With the development of the new large dose fractions of SRS, SBRT, more and more evidence indicates that the L-Q model is problematic and become less extending the data accumulated in conventional low dose to regions to high dose. The researchers proposed new mathematical models of radiobiology. Methods：This paper was presented LQ model, SH-MT model, ML-Q model, USC model, gL-Q model in chronological order. Results：the result of SH-MT model, ML-Q model and USC model are in good agreement with the experimental data.Conclusions：In comparison, USC model and gL-Q model may be more appropriate for the SRS and SBRT, However, the applicability and parameters of the USC model and gL-Q model need further confirmation.