探讨肌红蛋白的测定对于临床诊断不稳定型心绞痛的价值

目的：探讨临床检测肌红蛋白（Myoglobin，MYO）的浓度水平对于诊断不稳定性心绞痛（Unstable Angina Pectoris，UAP）的意义，为临床诊治提供依据。方法选择本院2012年10月-2013年6月间确诊为 UAP 的患者80例设为实验组，选择同期体检健康者80例设为对照组，两组的纳入对象分别检测血清 MYO 的浓度水平，并同时检测临床常用相关血清学指标同型半胱氨酸（Homocysteine，Hcy）、肌酸激酶（Creatine Kinase，CK）、肌酸激酶同工酶（MB Iso Enzyme of Creatine Kinase，CK-MB）的浓度水平，对最终检测结果进行合理分析。结果同对照组比较，实验组纳入对象的血清 MYO、Hcy 和 CK 的浓度水平有显著性升高，差异具有统计学意义（P ＜0．05）；血清 CK-MB 的浓度水平变化差异无统计学意义（P ＞0．05）；针对实验组患者按病情进行的不同分级中可见，血清中 MYO、Hcy 和 CK 的浓度水平随着患者病情的不断加重而呈现升高趋势，各级所检测结果与相应对照组的差异有统计学意义（P ＜0．05）；Ⅰ级和Ⅱ级血清 CK-MB 的浓度水平与相应对照组的差异无统计学意义（P ＞0．05），Ⅲ级的差异有统计学意义（P ＜0.05）；经过 ROC 曲线分析，对于不稳定型心绞痛病情的诊断效率依次为 MYO＞ Hcy＞CK＞CK-MB。结论血清MYO 的测定是一种诊断 UAP 的良好指标，其浓度水平的变化对于 UAP 患者的分级具有一定的参考价值。

To explore the clinical significance of the Unstable Angina Pectoris diagnosis by Myoglobin testing

Objective To explore the clinical significance of the Unstable Angina Pectoris diagnosis by Myoglobin testing,so as to provide the basis for the clinical diagnosis.Methods Choosing 80 cases of patients with UAP for the experimental group and 80 cases healthy check-up for the control group,and testing the MYO,Hcy,CK,CK-MB,ana-lyze the results comprehensively.Results Compared to the control group,there were significantly increased of the MYO,Hcy and CK of the patients in the experimental group （P 〈0.05）,but not for the CK-MB （P 〉0.05）;it was showed a gradual upward trend of the MYO,Hcy and CK with the sicker ,and there was also obviously difference （P 〈0.05）,but not for the CK-MB of the patients within Ⅰand Ⅱstage （P 〉0.05）eccept the Ⅲ stage;by the ROC curve analysis,the condition for unstable angina diagnostic efficiency were MYO 〉 Hcy 〉 CK 〉 CK-MB.Conclusion There is a good index of the MYO for the UAP diagnosis,and it is valuable for the classification of the UAP.