Isolation and structure of cytostatic steroidal saponins from the African medicinal plant Balanites aegyptica. |
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| Authors: | G R Pettit D L Doubek D L Herald A Numata C Takahasi R Fujiki T Miyamoto |
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| Institution: | Cancer Research Institute, Arizona State University, Tempe 85287. |
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| Abstract: | Bioactivity-guided separation of a CH2Cl2/MeOH extract of Balanites aegyptica afforded four new cytostatic saponins, named balanitins 4 1], 5 2], 6 3], and 7 4]. On the basis of enzymatic hydrolyses and glycosidation nmr chemical shifts employing the peracetates, structures 1-4 were established as yamogenin 3 beta-O-beta-D-glucopyranosyl-(1----3)-beta-D-glucopyranosyl-(1----4)-al pha- L-rhamnopyranosyl-(1----2)]-beta-D-glucopyranoside 1], yamogenin 3 beta-O-alpha-L-rhamnopyranosyl-(1----3)-beta-D-glucopyranosyl-(1----4)- alpha-L-rhamnopyranosyl-(1----2)]-beta-D-glucopyranoside 2], yamogenin 3 beta-O-beta-D-glucopyranosyl-(1----4)-alpha-L- rhamnopyranosyl-(1----2)]-beta-D-glucopyranoside 3], and diosgenin 3 beta-O-beta-D-xylopyranosyl-(1----3)-beta-D-glucopyranosyl-(1----4)-alp ha- L-rhamnopyranosyl-(1----2)]-beta-D-glucopyranoside 4]. |
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