IL-10 inhibits ICAM-1 expression on human Langerhans cells but not on keratinocytes, dermal endothelial cells or fibroblasts |
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| Authors: | R Chatelain Andreas Wollenberg Corina Martin Andrea Panhans-Gross Thomas Bieber Klaus Degitz Marc Heckmann |
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| Institution: | (1) Department of Dermatology, Ludwig-Maximilians-University, Frauenlobstrasse 9–11, Munich, Germany Fax +49 89 5160 4664, DE;(2) Department of Dermatology, Friedrich-Wilhelms-University, Sigmund Freud Strasse 25, 53105 Bonn, Germany, DE |
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| Abstract: | Abstract Intercellular adhesion molecule-1 (ICAM-1) is regularly expressed or inducible on all major cutaneous cell populations including
Langerhans cells, keratinocytes, endothelial cells and dermal fibroblasts. ICAM-1 is induced in the skin under inflammatory
conditions and plays an important role in the activation of T cells. Interleukin-10 (IL-10) is a pluripotent immunosuppressive
cytokine that inhibits proliferation of T cells via inhibition of antigen-presenting cells including Langerhans cells. We
demonstrates that IL-10 inhibits baseline and also cytokine-stimulated ICAM-1 expression on human Langerhans cells, which
has previously been shown in the murine system. No effect of IL-10 was seen on human dermal vascular endothelial cells, which
like Langerhans cells are also able to present antigen. Additionally, no inhibitory effect of IL-10 was observed on the ICAM-1
expression of keratinocytes and dermal fibroblasts. As IL-10 only weakly suppresses MCH II on human Langerhans cells, inhibition
of ICAM-1 and other accessory molecules by IL-10 seems to be an important mechanism inhibiting the antigen-presenting function
of human Langerhans cells.
Received: 9 December 1997 |
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| Keywords: | ICAM-1 Interleukin-10 Cytokines Langerhans cells Human skin |
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