额叶肿瘤患者认知功能和事件相关电位P300的研究

目的 探讨额叶肿瘤患者认知功能的损害和事件相关电位P300有关参数的变化特点,了解额叶在认知功能及P300产生中的作用.方法 对31例额叶肿瘤患者(左侧15例、右侧16例)及30例健康对照者分别进行Stroop字色干扰等多项认知神经心理学测试和P300检查.结果 与健康对照组相比,额叶肿瘤组认知功能各项测试指标评分均显著降低(P＜0.05),P300的N2、P3波潜伏期显著延长(P＜0.05),P3波幅显著降低(P＜0.05).进一步研究发现,右额叶肿瘤组患者的各项认知测试指标评分均显著低于健康对照组(P＜0.05),而左额叶肿瘤组只有词语流畅性指标评分显著低于健康对照组(P＜0.05);与健康对照组相比,左、右额叶肿瘤组P300的N2、P3波潜伏期均显著延长(P＜0.05),P3波幅均显著降低(P＜0.05);左、右额叶肿瘤组患者之间的P300比较则无统计学差异(p＞0.05).结论 额叶肿瘤患者认知功能有明显损害,右侧肿瘤患者的认知功能损害更严重:额叶可能与P300发生或传导有关,且左右额叶无明显的差异.

Cognitive function and P300 event-related potential of patients with tumor in frontal lobe

Objective To study the impairnlent of cognitive function and the change of P300 event-related potential(ERP)parameters in the patients with tumor in frontal lobe so as to investigate the role of the front lobe in cognitive function and the P300 production. Methods P300 examination and neuropsychological tests for cognition,including Stroop Test,Symbol Digit Modalities Test,and Verbal Fluency Test,et al,were performed in 31 patients with tumor in front lobe(left 15 and right 16)and 30 healthy controls. Results Compared with healthy controls, in the patients with front lobe tumor,cognitive function was degraded(P＜0.05),the latency of N3,P3 of P300 was significantly longer,and the amplitude of P3 was significantly lower(P＜0.05).Funhermore,the patients with tumor in right front lobe had signmcantly lower scores in cognitive tests compared with healthy controls (P＜0.05), but the ones with tumor in left front lobe were demonstrated obviously impaired only in Verbal Fluency Test(P＜0.05).Compared with healthy controls, the patients with tumor in eimer right or left flront lobe, the latency of N3,P3 of P300 was significantly longer,the amplitude of P3 was significantly lower(P＜0.05),while in the comparison of two sides, there was no statistically significantly difference in P300 (P＞0.05).Conclusions The cognitive function is obviously impaired in the patients with tumor in frontal lobe,and the impainnent is more serious in the ones with right frontal lobe tumor. Frontal lobe may be related to the generation and transmission of P300,and it is not significantly different in between left and right frontal lobes.