| 阿魏酸钠缓释小丸的制备及体外释药特性 |
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| 引用本文： | 张立超,全山丛,胡晋红,周德波,吕艳红.阿魏酸钠缓释小丸的制备及体外释药特性[J].中成药,2006,28(10):1414-1416. |
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| 作者姓名： | 张立超 全山丛 胡晋红 周德波 吕艳红 |
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| 作者单位： | 1. 第二军医大学附属长海医院药学部,上海,200433
2. 烟台警备区门诊部,山东,烟台,264000 |
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| 基金项目： | 上海市科学技术委员会中药现代化科研计划项目(03Z19526) |
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| 摘 要： | 目的:制备阿魏酸钠(SF)缓释小丸,初步评价其体外释药特性及释药机制。方法:离心造粒法制备空白丸芯及载药小丸;以乙基纤维素水分散体Surelease为包衣材料,流化床制备SF缓释小丸;释放度试验考察小丸的体外释药特性及释药机制。结果:包衣小丸表面光滑圆整,不同批次间小丸释药重现性良好;2种小丸配比而成的SF缓释胶囊释药随包衣膜厚的增加而减慢;后处理时间为24 h;小丸的体外释药符合H iguch i方程。结论:SF缓释小丸具有较理想的体外缓释效果。
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| 关 键 词： | 缓释小丸 离心造粒 流化床 包衣 阿魏酸钠 |
| 文章编号： | 1001-1528（2006）10-1414-03 |
| 收稿时间： | 10 16 2005 12:00AM |
| 修稿时间： | 2005-10-16 |
Preparation and release characteristics of sodium ferulate sustained-release pellets |
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| ZHANG Li-chao,QUAN San-cong,HU Jin-hong,ZHOU De-bo,L Yan-hong.Preparation and release characteristics of sodium ferulate sustained-release pellets[J].Chinese Traditional Patent Medicine,2006,28(10):1414-1416. |
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| Authors: | ZHANG Li-chao QUAN San-cong HU Jin-hong ZHOU De-bo L Yan-hong |
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| Institution: | 1. Changhai Hospital Affiliated to the Second Military Medical University, Shanghai 200433, China ; 2. Outpatient Department, Garrison Command in Qingdao , Yantai 264000, China |
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| Abstract: | AIM: To prepare the sodium ferulate sustained-release pellets and evaluate its release characteristics and release mechanism in vitro. METHODS: Sugar core beads and drug-containing pellets were prepared by centrifugal granulation,and then coated by Surelease using the fluid-bed.The release characteristics and release mechanism of the pellets were studied by the dissolution method. RESULTS: The surface of the coated pellets was smooth and glossy and round.The release rate of sodium ferulate met lot-to-lot uniformity.The release rate of the pellet consisted of two kinds of pellets decreased with the increasing of the film thickness.The finishing time was 24 h.The dissolution profiles of sodium ferulate from the pellets showed a good fit of the Higuchi equation.(CONCLUSION): The pellets exhibit more ideal sustained-release characteristics in vitro. |
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| Keywords: | sustained-release pellets centrifuation granulation fluid-bed coating sodium ferulate |
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