| 治疗偏头痛药佐米曲普坦制剂的研究进展 |
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| 引用本文： | 赵刚,苏庆,李静,田长青,孟晓东.治疗偏头痛药佐米曲普坦制剂的研究进展[J].中国新药杂志,2007,16(11):836-839. |
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| 作者姓名： | 赵刚 苏庆 李静 田长青 孟晓东 |
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| 作者单位： | 山东省医学科学院药物研究所,济南,250062 |
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| 摘 要： | 佐米曲普坦是一种高选择性、强效5-羟色胺1B／1D（5-HT18/1D）受体激动剂，可透过血脑屏障，同时具有外周和中枢作用，是目前治疗偏头痛较理想的药物之一。现就佐米曲普坦普通片剂、口腔崩解片和鼻喷剂的药动学、临床疗效及安全性和耐受性等进行综述。
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| 关 键 词： | 佐米曲普坦 偏头痛 药动学 临床疗效 安全性 |
| 文章编号： | 1003-3734（2007）11-0836-04 |
| 收稿时间： | 2006-12-10 |
| 修稿时间： | 2006-12-10 |
Research progresss in the formulation of anti-migraine drug zolmitriptan |
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| ZHAO Gang,SU Qing,LI Jing,TIAN Chang-qing,MENG Xiao-dong.Research progresss in the formulation of anti-migraine drug zolmitriptan[J].Chinese Journal of New Drugs,2007,16(11):836-839. |
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| Authors: | ZHAO Gang SU Qing LI Jing TIAN Chang-qing MENG Xiao-dong |
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| Institution: | Institute of Materia Medica, Shandong Academy of Medical Science, Jinan 250062, China |
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| Abstract: | Zolmitriptan is a highly selective 5-HT1B/1D receptor agonist.It can pass through blood-brain barrier and take effect on both periphery and central nerve system.At present it is the one of ideal drugs in the management of migraine.The pharmacology,pharmacodynamics,clinical efficacy,safety and tolerability of the zolmitriptan formulations(common tablets,orally disintegrating tablets,nasal spray) were reviewed. |
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| Keywords: | zolmitriptan migraine pharmacodynamics clinical efficacy safety |
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