42株嗜麦芽寡养单胞菌的分布与耐药性分析

目的了解嗜麦芽寡养单胞菌临床分布及耐药情况。方法细菌鉴定采用美国德灵公司Microscan Walkaway-40全自动细菌鉴定仪,PCIZ和NC11复合鉴定板进行体外药敏试验;数据处理应用WHONET5.3软件分析。结果自2005年1月-2006年9月临床送检标本中,共分离并鉴定嗜麦芽寡养单胞菌42株,选取常用的15种抗菌药物进行药物敏感试验结果显示,嗜麦芽寡养单胞菌对复方新诺明耐药率最低,为21.4%;其次为头孢哌酮/舒巴坦,耐药率为23.8%;对其他大多数抗菌药物也呈高度耐药;对亚胺培南和氨曲南耐药率为100.0%。结论嗜麦芽寡养单胞菌具有天然广谱耐药性,对该菌应加强监测与控制。

Distribution and Drug Resistance of 42 Stenotrophomonas maltophilia Isolates

OBJECTIVE To investigate distribution and drug resistance status of Stenotrophomonas maltophilia.METHODS Microscan WalkAway-40 automatic analyzer from American Dade Company was used to identify bacteria.PCIZ and NC11 combination plate was used to perform susceptibility test in vitro.The data were analyzed by WHONET5.3 software.RESULTS The susceptibility to 15 antibiotics was tested in 42 clinic isolates of S.maltophilia from Jan 2005 to Sept 2006.The drug susceptibility test showed that SMZ-TMP had the lowest resistance rate(21.4%).Then resistance rate of S.maltophilia to cefoperazone-sulbactam was 23.8%.And 100.0% isolates were resistant to imipenem and aztreonam.CONCLUSIONS S.maltophilia has natural broad-spectrum resistance.We should strengthen its monitoring and control.