Anti-ulcer polysaccharides from Cola cordifolia bark and leaves |
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Authors: | Ingvild Austarheim Haidara Mahamane Rokia Sanogo Adiaratou Togola Mehdi Khaledabadi Anne C Vestrheim Kari T Inngjerdingen Terje E Michaelsen Drissa Diallo Berit S Paulsen |
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Institution: | 1. School of Pharmacy, University of Oslo, 0316 Oslo, Norway;2. Department of Traditional Medicine, P. Box 1746, Bamako, Mali;3. Norwegian Institute of Public Health, 0456 Oslo, Norway |
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Abstract: | Ethnopharmacological relevanceAqueous extracts of bark and leaves of C. cordifolia are traditionally used in Mali (West Africa) in the treatment of wounds and gastric ailments like abdominal pain, gastritis and gastric ulcers.Aim of the studyTo evaluate and compare the anti-ulcer and immunological activities, as well as the toxicity of polysaccharide rich water extracts from the bark and leaves of C. cordifolia.Materials and methodsGastric ulcers were induced in rats and the inhibition of ulcer formation was calculated based on lesion index. Immunological activities were measured by complement fixation and macrophage activation. Toxicity was tested on brine shrimps. The two extracts were characterised by GC, Yariv-precipitation and quantification of phenolic compounds. An ethnomedical survey on C. cordifolia was carried out in Siby (Mali, West-Africa) to generate more knowledge about the traditional use.ResultsBark and leaf extracts from C. cordifolia significantly inhibited the formation of gastric lesions in rodents in a dose depending manner. CCbark50 showed a high complement fixation activity in vitro. No toxicity was found. The ethnomedical survey showed that C. cordifolia was mainly used for treating pain and wounds.ConclusionsOur results shows that the bark and the leaves comprise a dose dependant anti-ulcer activity in an experimental rat model (no statistical difference between the plant parts). Clinical studies should be performed to evaluate the effect of both bark and leaves of C. cordifolia as a remedy against gastric ulcer in human. |
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Keywords: | Cola cordifolia Anti-ulcer Polysaccharides Immunomodulation Toxicity Wound healing |
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