| 乳腺癌患者MRP基因表达及临床意义 |
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| 引用本文： | 唐利立,刘少华,蹇在伏,陈方平,海健,解勤之,费慧娟. 乳腺癌患者MRP基因表达及临床意义[J]. 中国肿瘤临床, 2000, 27(1): 41-43 |
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| 作者姓名： | 唐利立 刘少华 蹇在伏 陈方平 海健 解勤之 费慧娟 |
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| 作者单位： | 1. 湖南医科大学湘雅医院肿瘤科,长沙市,410008
2. 湖南医科大学湘雅医院血液研究室,长沙市,410008 |
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| 摘 要： | 目的：检测ＭＲＰ基因在人乳腺癌组织中的表达状况，初步分析其临床意义。方法：３７例待手术腺癌患者随机分为直接手术１、术后化疗、术前化疗和三苯氧胺三组。采用ＲＴ－ＰＣＲ法检测癌组织中ＭＲＰ基因表达。结果：本前化疗组ＭＲＰ阳性率２８．６％；直接手术组ＭＲＰ极弱或无表达；加用三苯氧胺ＭＲＰ表达减少为１／８。局部晚期病例ＭＲＰ基因表达多呈阳性。结论：以上结果提示ＭＲＰ是乳腺癌ＭＤＲ产生的机制之一。
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| 关 键 词： | 乳腺癌 多药耐药性 MRP基因 基因表达 |
MRP Expression in Primary Breast Carcinoma and Its Clinical Significance |
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| Tang Lili Liu Shaohua Jian Zaifu et al. MRP Expression in Primary Breast Carcinoma and Its Clinical Significance[J]. Chinese Journal of Clinical Oncology, 2000, 27(1): 41-43 |
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| Authors: | Tang Lili Liu Shaohua Jian Zaifu et al |
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| Affiliation: | Tang Lili Liu Shaohua Jian Zaifu et alDepartment of Oncology,Xiangya Hospital,Hunan Medical University,Changsha |
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| Abstract: | Purpose: This research is to investigate the expression of multidrug resistance associated protein (MRP)in primary breast carcinoma and to evaluate its clinical signification. Methode: The expression of MRP in 37 cases of breast carcinoma were assayed by RT-PCR. Eight patients were not treated with chemotherapy before operation, 21 patients were treated with chemotherapy, the other 8 patients were treated by chemotherapy plus Tamoxifen. Results: The expression of MRP in patients treated with chemotherapy was higher (6/21) than that of untreated patients (0/8), P< 0.01. The overexpression of MRP appeared in most patients who had local advanced breast cancer (5/9), P< 0.05. Conclusion: These results suggest that MRP gene expression in breast cancer is most likely induced by chemotherapy and that it is associated with progress of breast cancer. |
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| Keywords: | Breast neoplasm MRP Neoadjuvant chemotherapy Multidrug resistance |
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