假尿嘧啶核苷的高效液相色谱法测定及其与原发性肝癌的关系

应用高效液相色谱法（ＨＰＬＣ）测定了８０例原发性肝癌、３１例肝良性占位病变、４２例肝硬化、３８例健康志愿者血、尿中假尿嘧啶核苷（ＰＤ）的含量。结果显示，假尿嘧啶核苷的含量在原发性肝癌组升高显著；原发性肝癌ＰＤ阳性率７１．３％（５７／８０）；肝良性占位病变和健康组均无阳性病例；肝硬化组ＰＤ阳性者２例。对于原发性肝癌的诊断及预后判断有较好的指导作用。

DETERMINATION OF PSEUDOURIDINE BY HPLC AND IT'S CLINICAL USE FOR PRIMARY CARCINOMA OF LIVER

Serum and urine pseudouridine(PD)was measured by using HPLC in 80 patienta with primary carcinoma of liver,32 patients with benign space occupying liver lesions,42 patients with hepatic cirrhosis and 38 healthy blood donors.The results showed that PD in serum and urine of liver cancer patients was significantly increased.The PD positive rate was 71.3% in primary carcinoma of liver,while no PD positive case discovered in the 3 control groups except two positive cases observed in hepatic cirrhosis.The clinical use of PD for primary carcinoma of liver was discussed.