Clinical implications of mast cell–bacteria interaction |
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Authors: | R Malaviya Soman N Abraham |
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Institution: | (1) Department of Allergy and Inflammatory Diseases, Wayne Hughes Institute, St. Paul, MN 55113, USA, US;(2) Department of Pathology and Microbiology, Duke University Medical Center, Durham, NC 27710, USA, US |
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Abstract: | Mast cells are traditionally known for mediating allergic reactions. In addition, these cells have been implicated in the
pathogenesis of a variety of clinical conditions such as atopic and contact dermatitis, bullous pemphigoid, fibrotic lung
disease, neurofibromatosis, psoriasis, scleroderma, rheumatoid arthritis, interstitial cystitis, ulcerative colitis, and Crohn’s
disease, but their role in host defense was an enigma until recently. Owing to the strategic location of mast cells at the
host environment interface, their role in bacterial infections has been studied by a number of investigators. Latest reports
show that mast cells have an ability to modulate the host’s innate immune response to infectious agents. This review discusses
the clinical implications of mast cell-bacteria interactions.
Received: 13 August 1997 / Accepted: 7 April 1998 |
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Keywords: | Infection Inflammation Allergy Cytokines Innate immunity |
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