| Study on QSAR of Taxol and its Derivatives Based on Stepwise Multivariate Linear Regression Analysis |
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| 引用本文： | 刘艾林,迟翰林. Study on QSAR of Taxol and its Derivatives Based on Stepwise Multivariate Linear Regression Analysis[J]. 中国药学, 1997, 0(1) |
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| 作者姓名： | 刘艾林 迟翰林 |
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| 作者单位： | 中国医学科学院、中国协和医科大学药物研究所 |
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| 摘 要： | 应用逐步多元线性回归方法，对紫杉醇及其衍生物的两个异构体系进行了构效关系研究，发现Ｃ１３位侧链中的Ｃ３＇位取代基的摩尔折射与其活性密切相关，从而可以推断出Ｃ３′位取代基的改变很可能是其生物活性变化的重要因素，这为设计与合成活性较高的紫杉醇类似物将提供有价值的参考信息。
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| 关 键 词： | 紫杉醇；逐步多元线性回归（SMLR）；摩尔折射 |
Study on QSAR of Taxol and its Derivatives Based on Stepwise Multivariate Linear Regression Analysis |
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| Ai Lin Liu and Han Lin Chi Institute of Materia Medica,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing. Study on QSAR of Taxol and its Derivatives Based on Stepwise Multivariate Linear Regression Analysis[J]. Journal of Chinese Pharmaceutical Sciences, 1997, 0(1) |
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| Authors: | Ai Lin Liu Han Lin Chi Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing |
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| Affiliation: | Ai Lin Liu * and Han Lin Chi Institute of Materia Medica,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100050 |
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| Abstract: | |
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| Keywords: | Taxol Stepwise multivariate linear regression (SMLR) Molar refractivity |
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