The influence of genetic polymorphisms of GSTP1 on the development of asbestosis |
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Authors: | Franko Alenka Dolzan Vita Arneri? Niko Dodic-Fikfak Metoda |
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Institution: | Clinical Institute of Occupational Medicine, University Medical Center Ljubljana, Poljanski nasip 58, Ljubljana, Slovenia. alenka.franko@siol.net |
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Abstract: | OBJECTIVE: Genetic factors play an important role in the development of asbestosis. The aim of this study was to investigate whether genetic polymorphisms of glutathione S-transferase (GST) P1 represent a risk factor for this disease. METHODS: The study population included 262 workers with asbestosis and 265 matched controls. Information on cumulative asbestos exposure was available. A real-time PCR based on the 5' nuclease assay was designed for the analysis of GSTP1 Ile105Val and Ala114Val polymorphisms. RESULTS: Asbestosis was associated with GSTP1 genotype coding for an enzyme with high conjugation capacity versus genotypes resulting in intermediate and low enzyme activity (odds ratio = 1.49, confidence interval = 1.06-2.10). CONCLUSIONS: The key finding of the study was that GSTP1 genotype coding for an enzyme with high conjugation capacity significantly increases the risk of developing asbestosis. |
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