安徽省首例W135群流行性脑脊髓膜炎病例调查

目的 了解安徽省首例W135群流行性脑脊髓膜炎(流脑)病例的发病特点及流行病学特征,及时掌握安徽省流脑菌群变迁动向。 方法 查阅病例的病案资料;开展流行病学调查;采集病例血标本、密切接触者咽拭子标本进行病原培养和基因型别检测。 结果 患者临床表现为高热、剧烈头痛、呕吐、惊厥、皮肤瘀点瘀斑、休克等;无流脑疫苗免疫史,无流脑病例或疑似流脑病例接触史。从病例血液标本中检出1株W135群脑膜炎奈瑟菌(Nm),从病例密切接触者咽拭子标本中检出4株W135群Nm。对病例Nm和2株密接Nm进行MLST基因序列检测,结果均为ST-11型。 结论 该病例为安徽省首例W135群流脑病例,其MLST基因序列为ST-11型。

Investigation of the first case of Neisseria meningitidis W135 infection in Anhui

Objective To understand the clinical and epidemiological characteristics of the first case of meningococcal disease caused by Neisseria meninggitidis W135 in Anhui province and the change trend of N. meninggitidis serogroups Methods The case survey was conducted. The blood sample was taken from the case and the throat swabs were taken from close contacts to conduct the culture and genotyping of the pathogens. Results The clinical symptoms of the case included fever, severe headache, convulsion, vomiting, skin petechiae and shock. The case had no meningococcal disease vaccination history and meningococcal disease case contact history. One strain of N. meninggitidis W135 was isolated from the case’s blood sample and 4 stains of N. meninggitidis W135 were isolated from the close contacts’ throat swabs. MLST analysis indicated that the strain from the case and 2 strains from close contacts belonged to ST-11. Conclusion This was the first meningococcal disease case caused by N. meninggitidis W135 (ST-11) in Anhui province.