中药慢肝消治疗酒精性肝病的临床研究

目的观察中药复方慢肝消对酒精性肝病的治疗效果．方法酒精性肝病９２例，分治疗组６４例，对照组２８例．治疗组用慢肝消，对照组用加味逍遥散．治疗组和对照组中脂肪肝分别为１３例（１２０％）和９例（３２１％），肝炎分别为１９例（２７７％）和６例（３２１％），肝硬变分别为２２例（３４４％）和９例（３２１％），混合型各为１０例（１５６％）和４例（１４３％）．临床主要表现为纳呆、腹胀、胁胀或痛，呕恶便溏，乏力．３ｍｏ１疗程，观察结束后，对症状、体征、肝功能、胶原代谢，及免疫功能等方面的变化进行分析研究．结果治疗组临床治愈５例，显效３６例，好转１９例，无效４例，总有效率为９３８％，对照组临床治愈０例，显效１２例，好转８例，无效８例，总有效率为７１４％．结论慢肝消具有改善肝功能，抗肝纤维化，调解免疫功能的作用，明显优于对照组

Clinical study of Manganxiao in treatment of alcoholic liver diseases *

AIM To observe the therapeutic effect of traditional Chinese medicine decoction Manganxiao in alcoholic liver diseases. METHODS Ninety two patients with alcoholic liver diseases were treated with Manganxiao for 3 months. They were divided into treatment group (64 cases) and control group (28 cases). Traditional Chinese medicine decoction Manganxiao was used in treatment group, and traditional Chinese medicine decoction Xiaoyaosan was used in control group. In these two groups,there were 13(12%)and 9(32.1%) patients with fatty liver;19 (27 7%) and 6 (21 4%) hepatitis;22 (34 4%) and 9 (32 1%) cirrhosis;and 10 (15 6%) and 4 (14 3%) mixed types. The clinical manifestations were anorexia, abdominal distension, distension or pains of the hypochondrium, nausea, loose stool and feebleness. One course of treatment was three months. After treatment, the changes of patients' symptoms, signs, liver function, changes of collagen and the improved function of immunity were studied and analysed. RESULTS After 3 month treatment with Manganxiao in treatment group, 5 patients were recovered, 36 effective, 19 improved, and 4 ineffective with a total efficacy rate of 93 8%. In control group, no patient was recovered, 12 effective, 8 improved, and 8 ineffective with a total efficacy of 71 4%. CONCLUSION Manganxiao can improve liver function and the function of immunity and constitution and resist fibrosis.