血清肿瘤标志物检测在孤立性肺内结节诊断中的价值

目的探讨NSE、CEA、CYFRA21-1和TSGF检测在孤立性肺内结节诊断中的价值。方法回顾性分析孤立性肺内结节手术治疗病例412例，分别比较4种肿瘤标志物在肺癌组和良性疾病组的表达水平，比较4种肿瘤标志物在不同组织类型肺癌中的表达水平，比较CEA和TSGF单独检测和联合检测诊断肺癌的敏感性和特异性。结果在孤立性肺内结节病例中，肺癌患者的CEA和TSGF水平均明显高于良性疾病组，差异有统计学意义，而NSE、CYFRA21-1虽然高于良性疾病组，但无统计学意义。TSGF在4种类型肺癌中的表达无明显差异；NSE在小细胞肺癌中、CYFRA21-1在鳞癌中、CEA在腺癌中的水平明显高于其他类型的肺癌。CEA和TSGF对孤立性肺内结节中肺癌的诊断具有较高的敏感性，两种标志物联合检测，敏感性明显增加（P〈0．05）。结论在孤立性肺内结节的诊断中，应用CEA和TSGF组合对肺癌的诊断有较高的灵敏度，具有较高的应用价值。

Diagnostic utility of serum tumor markers in the solitary palmonary nodule

Objective To explore the value of the tumor marker（NSE, CEA, CYFRA21-1 and TSGF） in the diagnosis of solitary pulmonary nodule .Methods Retrospectively analyzed 412 cases of solitary pulmonary nodule treated by surgery. To compare the tumor marker level in lung cancer group and the benign group. To compare the tumor marker level in different histologie group. To analyze the diagnosis sensitivity of CEA and CYFRA21-1 with lung cancer and specificity in lung benign disease group. Results The levels of tumor marker in lung cancer group were higher than that of the benign disease group. But CEA and TSGF have statistic differ- ence. NSE and CYFRA21-1 have not. The level of TSGF has no difference in different lung cancer groups. CEA and TSGF have high diagnosis sensitivity with lung cancer and the CEA ＋ TSGF association increased the sensitivity. Conclusion Combination of CEA and TSGF can increase the clinical diagnosis value with lung cancer in solitary pulmonary nodule.