血清前白蛋白、胆碱脂酶、总胆汁酸在肝硬化中的检测价值

目的：探讨血清前白蛋白（prealbumin,PAB）、胆碱脂酶（cholinesterase,ChE）、总胆汁酸（total bile acid,TBA）在肝硬化中的检测价值。方法：测定105例肝硬化患者和30例健康人的前白蛋白、胆碱脂酶、总胆汁酸活性及肝功能生化指标,并按Child-Pugh分级进行比较。结果：肝硬化组前白蛋白含量、胆碱脂酶活性均较对照组显著降低;按Child-Pugh分级比较,肝硬化组前白蛋白含量在ChildA级与对照组、B级与A级之间、在C级与B级之间差异有显著性（P〈0.01）;胆碱脂酶活性在ChildA级与对照组、B级与A级、C级与B级之间差异有显著性（P〈0.01）。总胆汁酸在ChildB级与A级,C级与B级间有显著差异性,在A级与对照组间差异无显著性。结论：血清前白蛋白、胆碱脂酶在肝硬化早期评估中有很重要的价值,而总胆汁酸在肝硬化预后的判定中有重要价值。

The Clinic Value of Prealbumin,Cholinesterase and Total Bile Acid in Evaluating Liver Reserve Function in Patients with Liver Cirrhosis

Objective：To evaluate the role of prealbumin （PAB）,cholinesterase （ChE）,and total bile acid （TBA） in evaluating liver reserve function in patients with liver cirrhosis.Methods：One hundred and five serum samples from patients with liver cirrhosis were detected in PAB,ChE,TBA and other biochemical markers.All patients were classified in accordance with Child-Pugh scale.Results：For PAB,the differences among Child-Pugh A,B,C and healthy group were statistically significant （t=1.254,1.887,2.316） （P〈0.01）.For ChE,the differences among Child-Pugh A,B,C and healthy group were statistically significant （t=1.288,0.856,1.002） （P〈0.01）.For TBA,the differences among Child-Pugh C group,B group and A group were statistically significant （t=0.526,1.081）（P〈0.01）,the difference among Child-Pugh A group and healthy group was not statistically significant （t=5.615） （P〉0.05）.Conclusion：PAB and ChE reflect liver reserve function earlier in patients with liver cirrhosis.The role of TBA is important in reflecting prognosis in patients with liver cirrhosis.