血清C反应蛋白对急性心肌梗死的预后价值

目的：观察血清C-反应蛋白（CRP）水平与急性心肌梗死（AMI）患者6个月时心功能及病死率的关系。方法：入选我院572例AMI住院患者,根据入院时CRP水平分为CRP升高组及CRP正常组,随访6个月,记录超声心动图结果及死亡例数。结果：两组基线资料无明显差异。与入院时CRP正常组比较,CRP升高组患者6个月时LVEDD、LVESD,住院期间及随访期间病死率显著增加,而6个月时LVEF显著降低（P〈0.05）。多因素分析结果显示入院时CRP升高是AMI患者住院期间及6个月病死率的独立危险因素。结论：血清CRP升高是AMI患者心功能及病死率的预测因素,关注AMI患者血清CRP水平,尽早开始控制,有利于改善AMI的预后。

Prognostic Value of C-Reactive Protein Levels on the Patients with Acute Myocardial Infarction

Objective：To investigate the prognostic value of serum C-reactive protein level on patients with acute myocardial infarction.Methods：A total of 572 patients with AMI in whom plasma CRP was measured within 6 hours after onset were studied.They were divided into 2 groups：group A（n = 119） with elevated CRP（≥0.3 mg/dL） on admission within 6 hours after onset and group B（n = 453） with normal CRP（〈0.3 mg/dL） within 6 hours after onset.All were followed up for 6 months.Left ventricle ejection fraction（LVEF）、left ventricular end diastolic dimension（LVEDD）、 left ventricular end systolic dimension（LVESD） and the number of death were measured.Results：There were no significant differences in baseline characteristics between the 2 groups.The in-hospital mortality and LVEDD,LVESD,the mortality during follow-up were significantly increased in group A than group B（P 〈 0.05）.But LVEF were decreased.Multivariate analysis showed that patients with elevated CRP was an independent risk factor for the mortality in-hospital and during follow-up.Conclusion：CRP levels after the onset of AMI was a powerful predictor of ventricular remolding and the mortality in-hospital and during follow-up.CRP levels should be paid more attention.