高血压病患者脂蛋白脂肪酶S447X基因多态性与认知功能障碍的关系研究

目的：研究高血压病患者脂蛋白脂肪酶（liportein lipase,LPL）S447X基因多态性与认知功能之间的关系。方法：对2008年1月至2008年11月在四川大学华西医院医院门诊就诊的原发性高血压患者190例,收集一般资料,采用国际通用的简易智力状况量表测验认知功能,计算认知评分,用聚合酶链反应-限制性片段长度多态性（PCRRFLP）技术测定LPL S447X基因多态性。同时测定胆固醇、甘油三酯、空腹血糖、空腹胰岛素及餐后2h血糖、餐后2h胰岛素水平。结果：高血压病患者认知功能正常组和认知功能障碍组组间LPLS447X基因的基因型和基因频率差异均无统计学意义（P〉0.05）,SS和SX频率分别为92.6%、7.4%,S和X等位基因频率分别为96.3%和3.7%。结论：LPL S447X基因多态性可能与高血压认知功能障碍无明显相关性。

Association of Lipoprotein Lipase Gene S447X Polymorphism and Cognitive Decline in Chinese Patients with Hypertension

Objective：To study the relationship between liportein lipase（LPL） S447X polymorphism and cognitive function in patients with primary hypertension.Methods：One hundred and ninety hypertensive patients from January 2008 to November 2008 in West China Hospital of Si Chuan University.We collected the general data and applied the Mini Mental State Examination to test the cognitive function and computed score.PCR-RELP method was used to analyze the LPL S447X gene polymorphism.Total cholesterol、triglyeride、fasting plasma glucose and postprandial blood sugar、fasting insulin and postprandial plasma insulin were collected.Results：In primary hypertensive patients,both of the genotype frequency and the allele frequency of the LPL S447X polymorphism were not different between the cognitive normal group and the cognitive impaired group（P0.05）.SS genotype was present in 0.926 of the population, SX genotype was present in 0.074 of the population,allele frequencies were 0.963 for S allele and 0.037 for X allele. Conclusion：This results suggest S447X polymorphism in LPL with primary hypertension may not be associated with cognitive impairment.And age and postprandial plasma insulin level are the risk factors of hypertensive cognitive impairment.