米索前列醇在早早孕人工流产术前的应用

目的：探讨米索前列醇片在初次早早孕（≤42天）人工流产术前应用的可行性、有效性及安全性。方法：将300例初次妊娠,孕周≤6周,拟行人工流产的妇女随机分为口服米索组100例（A组）、阴道放置米索组100例（B组）、未使用米索对照组（C组）。A组术前2h口服米索前列醇片400μg,B组术前2 h阴道放置米索前列醇片400μg。观察并比较术前用药的两组不良反应发生率、宫颈扩张效果、术中出血量、手术时间及术后宫颈粘连发生情况。结果：B组不良反应发生率低于A组,差异有统计学意义（P〈0.01）;A、B两组间术中宫颈扩张效果、术中出血量、手术时间及术后宫颈粘连发生率差异均无统计学意义（P〉0.05）,但与C组比较差异有统计学意义。结论：米索前列醇片口服和阴道放药都可作为初次早早孕人工流产术前的给药方法。更推荐不良反应较小的阴道放药。

Application for Misoprostol Before Induced Abortion for the First Early Pregnancy

Objective：To evaluate the feasibility,safety and efficacy of applying for Misoprostol before induced abortion for the first early pregnancy（≤42 days）.Methods：300 first early pregnant women who were choosing induced abortion were randomly and evenly divided into three groups.Cases in group A taked 400μg Misoprostol orally and cases in group B were placed 400μg Misoprostol transvaginally two hours before operation,Cases in group C（the control group） did not taking Misoprostol.To compare the incidence rate of adverse reactions,the effect of cervical dilatation,bleed volume in operation,operation time and the incidence rate of postoperative cervical adhesions between group A and B.Results：The incidence rate of adverse reactions in gronp B was significantly lower than that in group A（P〈0.01）.there were no significant differences in the effect of cervical dilatation,bleed volume in operation and operation time between group A and B（P〉0.05）,however,which were significant comparing with group C.Conclusion：Both taking Misoprostol orally and placed transvaginally can be a route administration applying for the first early pregnant women are choosing induced abortion,We especially recommend the latter because of less incidence rate of adverse reactions.