| 血管内皮生长因子在动脉粥样硬化斑块中的表达 |
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| 引用本文： | 朱泉芳,刘延玲,郝家骅,张宝仁,朱家麟,赵仙先.血管内皮生长因子在动脉粥样硬化斑块中的表达[J].第二军医大学学报,1999,20(9):669-671. |
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| 作者姓名： | 朱泉芳 刘延玲 郝家骅 张宝仁 朱家麟 赵仙先 |
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| 作者单位： | 1. 第二军医大学长海医院心血管内科,上海,200433
2. 第二军医大学长海医院胸心外科,上海,200433 |
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| 摘 要： | 目的：观察血管内皮生长因子（VEGF）在动脉粥样硬化斑块中的表达。方法: 利用高胆固醇饲料复制兔动脉粥样硬化模型，采用免疫组织化学方法，观察VEGF在胸主动脉粥样硬化斑块中的表达。结果：正常兔主动脉组织中未见VEGF蛋白阳性表达，而动脉粥样硬化斑块区VEGF蛋白表达明显增加。结论：动脉粥样硬化斑块中VEGF表达增加，并可能参与动脉粥样硬化发生和发展的病理过程。
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| 关 键 词： | 血管内皮生长因子 动脉粥样硬化 |
The expression of vascular endothelial growth factor in atherosclerotic plaques |
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| Zhao Xianxian,Zhu Jialin,Zhang Baoren,Hao Jiahua,Liu Yanling,Zhu Quanfan.The expression of vascular endothelial growth factor in atherosclerotic plaques[J].Academic Journal of Second Military Medical University,1999,20(9):669-671. |
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| Authors: | Zhao Xianxian Zhu Jialin Zhang Baoren Hao Jiahua Liu Yanling Zhu Quanfan |
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| Affiliation: | Zhao Xianxian, Zhu Jialin, Zhang
Baoren, Hao Jiahua, Liu Yanling,Zhu Quanfan
(Department of Cardiothoracic Surgery, Changhai Hospital,
Second Military Medical University, Shanghai, 200433) |
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| Abstract: | Objective:To investigate the expression of vascular endothelial growth factor (VEGF) in atherosclerotic plaques.Methods: The rabbit atherosclerotic model was developed by high cholesterol feeding.The VEGF protein level in atherosclerotic plaques were studied by means of immunohistochemistry.Results:VEGF protein was not detected in normal rabbit aortic arteries,the increased production of VEGF protein were found in atherosclerotic plaques.Conclusion:VEGF protein have a high level expression in atherosclerotic plaques and may involve the pathogenesis and progression of atherosclerosis. |
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| Keywords: | vascular endothelial growth factor atherosclerosis |
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