冠心病患者肺炎衣原体感染与C反应蛋白、纤维蛋白原相互关系的研究

目的 :了解冠心病患者肺炎衣原体感染与C反应蛋白 (CRP)、纤维蛋白原的相互关系 ,探讨其可能的发病机制。方法∶应用多聚合酶链反应 (PCR)技术检测了 5 4例冠心病患者 (急性心肌梗死 16例 ,不稳定型心绞痛 2 0例 ,稳定型心绞痛 18例 )血清肺炎衣原体DNA ,选 2 0例体检健康者作对照 ,同时用免疫浓度法检测各组血清CRP和血浆纤维蛋白原浓度。结果∶急性心肌梗死组 ,不稳定型心绞痛、稳定型心绞痛组肺炎衣原体DNA阳性率分别为 81.3%、75 %、6 6 .7% ,与对照组 2 5 %相比差异有显著性 (P <0 .0 1) ;稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组血清CRP浓度和血浆纤维蛋白原浓度显著高于正常对照组 (P <0 .0 1) ,并且与冠心病的严重程度呈正相关。直线相关分析显示冠心病患者CRP浓度和纤维蛋白原浓度之间存在显著正相关 (r =0 .96 2 ,P <0 .0 1) .结论∶冠心病患者肺炎衣原体感染率明显增高 ,肺炎衣原体可能通过炎症反应和凝血机能增强在冠心病的发生、进展中发挥重要作用

The relation between Chlamydia pneumoniae infection and serum levels of fibrinogen and C-reactive protein in patients with coronary heart disease

Objective: To investigate the relation between Chlamydia pneumoniae (CP) infection and serum levels of fibrinogen(Fg) and C reactive protein(CRP) in coronary heart disease(CHD).Methods:Serum CP DNA was examined using polymerase chain reaction (PCR) technique in 20 healthy subjects (Control) and 54 patients with CHD, including 16 cases of acute myocardial infarction (AMI), 21 of unstable angina (UAP) and 18 of stable angina(SAP) (38 angina patients were confirmed by angiography). The levels of fibrinogen and C reactive protein were measured with immunoassay.Results:Patients with AMI,UAP,SAP had significantly higher positive rate of CP DNA. The leve1s of plasma Fg and serum CRP were also significantly higher compared with control group ( P< 0.01). The levels of plasma Fg and serum CRP increased with degree of severeness of CHD. Linear analysis indicated that the serum concentration of CRP increased with increasing plasma Fg concentration (CRP is related positively to Fg) in patients with CHD ( r=0.962, P< 0.01). The patients who were CP DNA positive had significantly higher concentrations of Fg and CRP than those who were CP DNA negative. Conclusions: CP infection rate significantly increase in patients with CHD. CP infection may play a role in the pathogenesis of CHD through inflammation and enhancing the mechanism of blood coagulation.