粥样硬化性肾动脉狭窄相关因素分析

目的探讨粥样硬化性肾动脉狭窄与冠心病、肾功能之间的关系.方法 254例患者冠脉造影的同时行肾动脉造影.结果合并肾动脉狭窄的冠心病者较单纯冠心病患者冠脉多支病变(58%∶27%,P<0.05)及临床表现急性冠脉综合征者多(86% vs 72%,P<0.05);肾动脉狭窄组中轻度血肌酐升高者增多(33% vs 11%,P<0.05),60%的单侧肾动脉狭窄者狭窄侧肾脏缩小,肾动脉狭窄程度与分肾肾小球滤过率之间无相关性(r=-0.208, P>0.05).结论粥样硬化性肾动脉狭窄与冠心病、冠脉病变严重程度密切相关.血肌酐轻度升高可能是肾动脉狭窄的独立预测因素.

Analysis of Atherosclerotic Renal Artery Stenosis and Related Factors

Objective To investigate the correlation between atherosclerotic renal artery stenosis, coronary artery disease and renal function. Methods Two hundred and fifty-four patients with CAD or suspected CAD were carried out renal artery angiography after coronary angiography. Results Among the patients with CAD, patients with ARAS tended to have 3-vessel CAD and acute coronary syndrome(58% vs 27%, 86% vs 72%, P<0.05); Patients with mildly increasing level of serum creatinine were more in ARAS group than in control group (33% vs 11%, P<0.05). 60% patients with unilateral ARAS had asymmetric renal size. The lack of relationship between the degree of renal artery stenosis and GFR of individual kidney(r=-0.208, P>0.05) was observed.Conclusion ARAS was associated with CAD and the severity of CAD. Mildly elevated creatinine concentration may be an independent predictor of ARAS.