| 噻氯匹啶的抗血小板作用 |
| |
| 引用本文： | 倪立,陈小铭,凌树森,孙维林. 噻氯匹啶的抗血小板作用[J]. 医学研究生学报, 1995, 0(2) |
| |
| 作者姓名： | 倪立 陈小铭 凌树森 孙维林 |
| |
| 作者单位： | 南京军区南京总医院药理科!南京，210002 |
| |
| 摘 要： | 噻氯匹啶为抗血小板聚集药物，能抑制多种诱导剂所致的血小板聚集。大鼠灌服给药25～200mg／kg后，能明显降低外源性ADP、凝血酶、花生四烯酸诱导的血小板聚集，且呈一定的量效关系，等剂量（100mg／kg）的噻氯匹啶与经典药物阿斯匹林相比，二者抑制血小板聚集的作用相似；能明显抑制动脉血栓的形成，形成的血栓干重和湿重均低于等渗盐水对照组，且随剂量的增加而抑制作用增强。大鼠灌服噻氯匹啶后，能明显延长出血时间，并随剂量的增加而延长，但不影响血管壁PGI2活性。
|
| 关 键 词： | 噻氯匹啶 血小板聚集 血栓 出血时间 前列环素 6-酮-前列环素F_(1α) |
Inhibition of platelet aggregation by Ticlopidine |
| |
| Ni Li, Cheng Xiaomin, Lin Shushen,et al. Inhibition of platelet aggregation by Ticlopidine[J]. Bulletin of Medical Postgraduate, 1995, 0(2) |
| |
| Authors: | Ni Li Cheng Xiaomin Lin Shushen et al |
| |
| Affiliation: | Department of Pharmacology |
| |
| Abstract: | Ticlopdine was found to be a potent inhibitor on platelet aggregation when orally administered to rats. The effect of this compound widely covered against platelet aggregation induced by various stimulants including ADP,thrombin and arachidonate, and appeared dosedependently. The effect was as good as aspirin at dose of 100mg/kg. Ticlopdine could significantly inhibit the thrombosis fortnation in rats. The weights of wet and dry thrombosis were lighter as compared with that of saline group. Ticlopdine had no effect on PGI2. Ticlopdine was found to cause the bleeding tirne longer and this time would be much longer when high ter dose of this drug was given to mouse. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
