激素对感染旋毛虫小鼠病理及免疫影响的动态观察

应用组织学及酯酶染色法动态观察了醋酸可的松对感染旋毛虫小鼠肌组织病理及免疫细胞的影响。实验结果发现,该药在使用期间可抑制虫体/囊包周围的炎症反应,使外周血Th减少,Ts增高,Th/Ts比值降低以及嗜酸粒细胞数减少,表明感染旋毛虫小鼠使用激素可降低机体的免疫力。

PATHOLOGICAL AND IMMUNOLOGICAL KINETIC OBSERVATIONS OF THE EFFECT OF HORMONE ON MURINE TRICHINOSIS

Female mice weighted 18-22g were infected with 100 larvae of Trichinella spi- ralis. The effect of cortison acetate on the pathology of muscle and the immune cells in peripheral blood were observed by histological and Acidnaphthyl esterase (ANAE)staining methods. The results showed that cortisone acetate could restrain the inflammatory reaction in the sur- roundings of larvae and encysted larvae. The number of Help T cells(Th) were decreased and that of supperesor T cells(Ts) were increased, leading to a drop down of the Th/Ts ratio. The number of eosinophils were decreased. it demonstrates that administration of cortisone acetate might su- press the immune function of mice infected with Trichinella spiralis.