血清孕酮及绒毛膜促性腺激素的检测在早期先兆流产中的临床意义

目的 分析探讨怀孕早期孕妇的血清孕酮及绒毛膜促性腺激素水平在早期先兆流产中具有的临床意义和价值. 方法 选取孕龄6-9周的孕早期孕妇221例,根据妊娠的结果将其分为继续妊娠组92例、最终流产组61例和健康对照组68例,采用全自动化学发光免疫分析仪分别对血清中的孕酮P和绒毛膜促性腺激素β-HCG水平进行检测. 结果 孕6~9周继续妊娠组各孕周P及β-HCG水平均显著低于健康对照组,最终流产组各孕周P及β-HCG水平均显著低于继续妊娠组（P〈0.05）差异有统计学意义,孕酮水平变化同β-HCG,差异有统计学意义. 结论 孕6~9周时血清P和β-HCG水平检测是孕妇早期先兆流产判定的有效手段,两者联合应用对先兆流产的临床诊断具有重要意义.

The clinical significance of serum progesterone and HCG detection on diagnosing threatened abortion

Objective To explore the clinical significance of serum progesterone （P） and human chorionic gonadotropin （HCG） levels in the diagnosis of early threatened abortion. Methods Two hundred and twenty-one cases of early pregnancys who had 6-9 weeks gestations were divided into continued gestation group （92 cases）, inevitable abortion group （61 cases） and healthy control group （68 cases）. The serum levels of P and β -HCG were detected by automated chemiluminescence immunoassay analyzer. Results The level of P and β -HCG of the continued gestation group were significantly lower than the healthy control group（P〈0.05）, and the level of P and β -HCG of the inevitable abortion group were significantly lower than the continued gestation group （P〈0.05）, which difference had statistically significant. Conclusion The combined detection of serum P and β-HCG levels in 6-9 weeks pregnancys were an effectively means of diagnosing threatened abortion, which had important clinical significance.