| 硫化氢与系统功能调节 |
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| 引用本文： | 史迪,俞佳,于学忠. 硫化氢与系统功能调节[J]. 中国急救医学, 2009, 29(11). DOI: 10.3969/j.issn.1002-1949.2009.11.002 |
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| 作者姓名： | 史迪 俞佳 于学忠 |
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| 作者单位： | 中国医学科学院,中国协和医学院,北京协和医院急诊科,北京,100730 |
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| 摘 要： | 硫化氢(H2S)在哺乳动物组织中大量产生,并且作为调节介质发挥多种理学效应.研究证明,H2S是继NO和CO之后发现的一种新的气体信号分子.H2S参与血管张力、心肌收缩力、神经递质和胰岛素分泌的调节,很多系统的功能调节与H2S有关.动脉高压、阿尔茨海默病、胃黏膜损伤和肝硬化的动物模型中均有H2S的缺乏,而外源性H2S可以改善与缺血/再灌注损伤相关的心功能不全,减少抗炎药物引起的胃黏膜损伤.本文对H2S在体内不同系统中的产生、功能调节及可能的作用机制进行综述,力求将H2S的系统功能调节作用展示出来.
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| 关 键 词： | 硫化氢 神经系统 心血管系统 内分泌系统 消化系统 |
Hydrogen sulfide and the regulation of system function |
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| SHI Di,YU Jia,YU Xue-zhong. Hydrogen sulfide and the regulation of system function[J]. Chinese Journal of Critical Care Medicine, 2009, 29(11). DOI: 10.3969/j.issn.1002-1949.2009.11.002 |
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| Authors: | SHI Di YU Jia YU Xue-zhong |
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| Abstract: | Hydrogen sulfide ( H_2S) is produced in mammalian tissues and have many physiolog-ical effects. Recent studies suggest that H_2S is the third gaseous mediator in mammals besides NO (ni-tric oxide) and CO (carbon monoxide). H_2S is involved in the regulation of angiotasis, myocardial con-tractility, neurotransmitter and insulin secretion. H_2S is associated with system function. H_2S deficiency was observed in various animal models of arterial and pulmonary hypertention, Alzheimer's disease, gas-tric mucosal injury and liver cirrhosis. Endogenous H_2S ameliorates myocardial dysfunction associated with the ischemia/reperfusion injury and reduces the damage of gastric mucosa induced by anti - inflam-matory drugs. We sum up the production, regulation function and possible mechanism of H_2S in different systems. |
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| Keywords: | Hydrogen sulfide (H_2S) Nervous system Cardiovascular system Endocrine system Digestive system |
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