Inhibition of Mg2+-Na+-K+-dependent ATPase system from human gastric mucosa by prostaglandins E1 and E2 |
| |
| Authors: | G Mózsik J Kutas L Nagy G Németh |
| |
| Affiliation: | 1. >First Department of Medicine University Medical School, 7643 Pécs, Hungary;1. First Department of Surgery, University Medical School, 7643 Pécs, Hungary |
| |
| Abstract: | The Mg2+-dependent and Na+K+-dependent (Na+K+-activated or transport) ATPase (EC 3.6.1.3.) were prepared from human fundic gastric mucosa and the effects of prostaglandins E1 and E2 on their activity studied.Significant inhibitions of Mg2+-dependent, total (Mg2+-dependent and Na+K+-dependent) and Na+K+-dependent ATPase activities were caused by prostaglandins E1 and E2, in concentrations of 10?9 to 10 ?6 M.A possible role of Mg2+Na+K+-dependent ATPase system is discussed in the inhibition of gastric secretion by type E prostaglandins. |
| |
| Keywords: | Human gastric mucosa Inhibition of gastric secretion Membrane ATPase system ATP-ADP system of cells Adenyl cyclase |
| 本文献已被 ScienceDirect 等数据库收录！ |
