Glycolipids of chick embryo fibroblasts infected with temperature-sensitive mutants of avian sarcoma viruses. |
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| Authors: | S I Hakomori J A Wyke P K Vogt |
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| Affiliation: | 1. Division of Biochemical Oncology, Fred Hutchinson Cancer Research Center, and Departments of Pathobiology and Microbiology, University of Washington, 1124 Columbia Street, Seattle, Washington 98104 USA;2. Department of Microbiology, University of Southern California, School of Medicine, 2025 Zonal Avenue, Los Angeles, California 90033 USA |
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| Abstract: | The effect of virus-induced transformation on the glycolipid pattern of chick embryo fibroblasts has been studied with mutants of avian sarcoma viruses which are temperature sensitive for the initiation and maintenance of transformation. The transformed state is associated with a three- to fivefold decrease in the level of hematoside. This decrease is temperature dependent with the mutants, and at the nonpermissive temperature normal cell morphology and behavior as well as normal hematoside levels are restored. The higher sialosyl glycolipids of chick embryo fibroblasts also decrease in transformation, but in mutant-infected cells at the nonpermissive temperature they do not return to normal levels. |
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| Keywords: | University of Southern California. Author to whom reprint requests should be addressed. |
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