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Regulation of chemosensitivity and migration by clusterin in non-small cell lung cancer cells |
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| Authors: | Ching-Yuan?Cheng,Shur-Hueih?Cherng,Wen-Jun?Wu,Tsung-Ying?Yang,Xin-Yi?Huang,Fu-Tien?Liao,Ming-Fang?Wu,Gwo-Tarng?Sheu author-information" > author-information__contact u-icon-before" > mailto:gtsheu@csmu.edu.tw" title=" gtsheu@csmu.edu.tw" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
| Affiliation: | (1) Division of General Thoracic Surgery, Department of Surgery, Changhua Christian Hospital, 135 Nanxiao St., Changhua City, Changhua County, 500, Taiwan;(2) Department of Biotechnology, Hung Kuang University, 34 Chung-Chie Rd, Sha Lu, Taichung City, 443, Taiwan;(3) Institute of Medicine, Chung Shan Medical University, Research Building Room 702, No. 110, Sec. 1, Jianguo N. Road, Taichung City, 402, Taiwan;(4) Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, No. 160, Sec. 3, Chung-Kang Rd., Taichung City, 407, Taiwan;(5) Department of Medical Oncology, Chung Shan Medical University Hospital, No. 110, Sec. 1, Jianguo N. Road, Taichung City, 402, Taiwan |
| Abstract: | PurposeIn terms of drug resistance, cancer cells usually benefit from high clusterin (CLU) expression on chemotherapy. In contrast, CLU expression has been found to be a favorable prognostic factor in lung cancer patients. The aims of this study are to determine the association between CLU expression and chemotherapeutic sensitivity and the potential role of CLU in migration in human non-small-cell lung cancer (NSCLC) cell lines. |
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