糖皮质激素对重症肌无力患者血清肿瘤坏死因子及白介素-6水平的影响

目的 探讨糖皮质激素(GC)对重症肌无力(MG)患者血清肿瘤坏死因子(TNF)及白细胞介素-6(IL-6)水平的影响。方法 选择48 例MG 患者(治疗组),采用GC治疗,疗程1个月,观察治疗前后患者血清TNF及IL-6的水平,并在治疗前与42例健康者(对照组)比较。结果 治疗组治疗前患者血清TNF、IL-6水平均明显高于对照组(P<0.05),经GC治疗1个月后治疗组患者血清TNF、IL-6 水平降低,与治疗前比较有明显差异(P<0.05)。结论 GC可能通过抑制MG患者体内TNF及IL-6的产生来调节患者的免疫功能。

The effect of glucocorticoid on serum tumor necrosis factor and IL-6 in patients with myasthenia gravis

ObjectiveTo analyse the effect of Glucocorticoid(GC)on serum tumor necrosis factor(TNF)and interleukin -6(IL-6)in the patients with myasthenia gravis(MG).Methods 48 MG patients(treatment group), which treated with GC for 1 months, were selected to observed the value in the serum of TNF and IL-6 before and after treatment, meanwhile, there were 42 healthy subjects(control group)chosen to be compared with treatment group before GC treatment to discover its therapeutic effect.Results Before the treatment carried out, the TNF and IL-6 serum of the treatment group were significantly higher than those of the control group, and the difference was statistically significant(P<0.05), after GC treatment of 1 months, the serum levels of TNF, IL-6 in the treatment group significantly reduced comparing with those of pretherapy, the difference was statistically significant(P<0.05).Conclusion The immune function of patients might be regulated from GC by inhibiting the production of TNF and IL-6 in patients with MG, and using the GC would have a great effect.