循环肿瘤DNA液体活检对妇科肿瘤早期筛查意义

某些妇科恶性肿瘤若能做到早期发现，会极大改善患者预后。液体活检是一种新兴技术，通过检测患者体液中某些肿瘤相关的改变，如寻找肿瘤细胞或肿瘤DNA，实现肿瘤的早期发现和诊断。该技术方法目前尚未臻成熟，仍处于临床前研究阶段。文章通过探讨循环肿瘤DNA液体活检的定义、特性、方法及应用等，综述其在妇科肿瘤早期筛查中的意义和未来的应用前景。

Circulating tumor DNA and liquid biopsy in early screening of gynecologic tumor.

Abstract: The early detection of some gynecologic malignancies can significantly improve patient’s prognosis. Liquid biopsy is a new technology that use human’s body fluid to detect tumor-relating changes，e.g., tumor cells or tumor DNAs，in order to early detect tumor status and make diagnosis, but this method is immature and still in the pre-clinical experimental stage. We discussed the definition，characteristics，methods and applications and reviewed the meaning of circulating tumor DNA detection and its future prospects.