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Case-control study on influencing factors of pathogenesis of autism spectrum disorders

??Objective Through the comparative analysis of influencing factor differences in the autistic spectrum disorders??ASD?? children and healthy children?? to further explore child autism factors and to provide reference for prevention and control of autism. Methods A retrospective investigation with 1??1 case-control study was conducted in 196 cases of ASD children and normal children diagnosed and treated in Jinzhou Women and Children’s Hospital between May 2014 and May 2015??through the home-made questionnaire for health factors??the differences between the two groups concerning development indicators and health influencing factors were compared. Results There was no statistical difference in the average height and weight between the two groups??P??0.05????but the size of head circumference of ASD group was greater than the control group??and the difference was statistically significant??t??2.41?? P??0.02??.Conditional logistic regression analysis revealed there was statistical difference??all P??0.05?? in children’s ability of a glimpse of recognition and understanding ??β??-3.077?? and head circumference ??β??0.341??. The test of regression coefficient of some variables showed that mother’s age older than 35 years old??family relationship??family history of neurological disorder and father engaged in manual labour had statistical significance??and were significantly correlated with the occurrence of diseases??all P??0.05??. Some factors had positive relationship with the happening of the disease??all P??0.05????namely irritable mood during pregnancy ??β??1.966?? OR??7.144????mental stimulation ??β??2.067?? OR??7.902?? and pregnancy vomiting ??β?? 2.576?? OR??13.138???? but supplements ??β??
-2.435?? OR??0.088?? and the normal quickening ??β??-2.008?? OR??0.134?? were negatively associated with ASD ??all P??0.05??. Conclusion The factors such as mother's age more than 35 years old?? father engaged in mental labour?? family tensions?? family history of nervous disorders?? mental stimulation?? emotional irritability and pregnancy vomiting?? may be the risk factors for ASD. If mother is pregnant before the age of 35?? has supplements timely and keep happy during pregnancy??and in the process of children’s growth??parents pay attention to development of language and head circumference?? and ofen accompany children?? the occurrence of ASD can be reduced to a certain extant.