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Influence of long-term inhalation of corticosteroids at low dose on the height of Chinese children with mild to moderate asthma

??Objective??To investigate the effects of long-term inhalation of corticosteroids at low dose on the height of Chinese children with mild to moderate asthma. Methods??From August 2015 to July 2016??a total of 966 prepubertal children aged 3.0 to 9.5 years from the Cooperative Group of Asthma??the Subspecialty Group of Respiration??the Society of Pediatrics??Chinese Medical Association were enrolled for the analysis of the cross-sectional questionnaire survey??in which 173 were asthmatic children who had received at least 12-month ICS treatment at low dose and stopped the ICS treatment at least 6 months before enrollment??415 were asthmatic children who had received any ICS treatment for no more than 2 months in a year or who didn’t receive ICS treatment??and 378 were healthy controls. The analysis of variance??ANOVA?? test was used to compare height standard deviation score??SDS??and height velocity among these three groups. The t test was used to analyze changes of height indicators across time in the long-term ICS treatment group. Results??No difference was found in the height SDS and weight SDS at enrollment??or in the height SDS and weight SDS one year before enrollment??or in growth velocity and weight velocity among these three groups. In the long-term ICS treatment group??the height SDS slightly decreased at withdrawal of ICS treatment??-0.62±2.75?? compared to that at the start of ICS treatment??-0.23±1.71?? and one year before enrollment??-0.20±2.91????but significantly increased after at least six monthsof withdrawalofICS??enrollment????0.15±1.39??. The height SDS after five years of treatment with ICS was -0.95±1.41??which was significantly reduced compared to the height SDS after one to three years of treatment??0.17±1.40??P??0.020?? or three to five years of treatment??0.32±1.27??P??0.013??. Conclusion??Long-term treatment????five years?? with ICS at low dose is not associated with height reduction in prepubertal children with mild to moderate asthma.