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“肺与大肠相表里”的研究进展
引用本文:王宪正,赵霞,狄留庆,汪受传,单进军.“肺与大肠相表里”的研究进展[J].世界科学技术-中医药现代化,2020,22(3):855-860.
作者姓名:王宪正  赵霞  狄留庆  汪受传  单进军
作者单位:南京中医药大学附属医院 南京210023;江苏省儿童呼吸疾病(中医药)重点实验室南京中医药大学中医儿科学研究所 南京210023;江苏省儿童呼吸疾病(中医药)重点实验室南京中医药大学中医儿科学研究所 南京210023;南京中医药大学药学院 南京210023
基金项目:国家自然科学基金委面上基金项目(81774156):聚焦肺泡微环境研究甘桔汤调控RSV感染脂质代谢紊乱的作用机制,负责人:单进军;江苏省自然科学基金(BK20161573):肠道菌群与RSV感染后肺部免疫相关性及金欣口服液干预作用,负责人:单进军;江苏省高校自然科学研究重大项目(16KJA360002):肠道菌群介导的虎杖调节RSV肺炎免疫功能研究,负责人:单进军。
摘    要:综述“肺与大肠相表里”的研究进展,为今后有关该理论的研究提供参考。通过对“肺与大肠相表里”理论研究、临床研究及实验研究的文献进行整理分析,认为理论研究方面主要涉及经脉络属、阴阳学说及藏象理论;临床研究方面,该理论主要用于指导药物治疗,包括肺病治肠及肠病治肺,针灸治疗应用较少;实验研究,主要从实体结构、粘膜免疫、肠道菌群等方面探讨,近年来有“肠-肺轴”的提法,研究方法及角度更多样。明确这些理论研究,将对“肺与大肠相表里”进一步、深层次的研究提供参考及方向。本文建议对“肺与大肠相表里”的研究要采用多种方法、融合多个领域,尤其是多种组学和系统生物学方法的应用,肺、大肠微生物研究与免疫学研究的结合。

关 键 词:肺与大肠相表里    大肠  肠-肺轴  肠道菌群
收稿时间:2019/8/28 0:00:00
修稿时间:2020/4/21 0:00:00

Research Progress of
Wang Xianzheng,Zhao Xi,Di Liuqing,Wang Shouchuan and Shan Jinjun.Research Progress of[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2020,22(3):855-860.
Authors:Wang Xianzheng  Zhao Xi  Di Liuqing  Wang Shouchuan and Shan Jinjun
Institution:Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China,Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China,Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China;College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China,Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China,Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, China;Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China
Abstract:This paper reviews the research progress of "Superficies-Interior Relationship between Lung and Large Intestine" and provides a reference for future research on this theory. Through collating and analyzing the literature of theoretical research, clinical research and experimental research on "Superficies-Interior Relationship between Lung and Large Intestine" theory, it is concluded that theoretical research mainly involves meridians and collaterals, yin-yang theory and viscera theory. In clinical research, this theory is mainly used to guide drug treatment, including lung disease treatment of intestinal and intestinal diseases, and acupuncture treatment is less used; The experimental research mainly focuses on the physical structure, mucosal immunity, intestinal flora and so on. Recently, there is a reference to the "the gut-lung axis", and the research methods and angles are more diverse. To clarify these will provide reference and direction for further and deeper research on "Superficies-Interior Relationship between Lung and Large Intestine". It is suggested that the study of lung and large intestine should adopt various methods, integrate multiple fields, especially the application of omics and system biology methods, and combine the study of lung and large intestine microorganisms with the study of immunology.
Keywords:Superficies-Interior Relationship between Lung and Large Intestine  lung  large intestine  the gut-lung axis  gut microbiota
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