不同分型急性白血病患者医院感染直接经济损失研究

目的探讨急性淋巴细胞白血病(ALL)与急性非淋巴细胞白血病(ANLL)患者医院感染所致的直接经济损失。方法收集2011年1月—2013年12月入住某医院血液病房的所有急性白血病(AL)成年患者,AL患者分别按照医院感染组(病例组)和未感染组(对照组)、ALL组和ANLL组进行1∶1配对,比较各组患者住院费用及住院时间等情况。结果共994例AL患者,其中ALL患者166例,ANLL患者828例,按照配比条件病例组和对照组共纳入181对,ALL组和ANLL组共纳入15对。ALL、ANLL患者医院感染直接经济损失分别为13 089.0、21565.0元;医院感染延长住院时间分别为10.5、10.0 d,病例组与对照组比较,差异均具有统计学意义(均P0.05)。ANLL病例组的总费用、床位费、诊疗费、治疗费、化验费、护理费、西药费、中药费、输血费绝对值均高于ALL对照组,但差异无统计学意义。结论 AL患者发生医院感染可导致住院费用增加,住院时间延长。

Direct economic losses due to healthcare associated infection in patients with different types of acute leukemia

ObjectiveTo investigate the direct economic losses caused by healthcare associated infection(HAI) in patients with acute lymphoblastic leukemia (ALL) and acute non lymphoblastic leukemia (ANLL).MethodsAll acute leukemia (AL) adult patients who were admitted to a hematology ward in a hospital between January 2011 and December 2013 were included in the study, HAI group(case group) and non HAI group (control group), ALL group and ANLL group were matched respectively in a 1:1 ratio, hospitalization expenses and length of hospital stay were compared.ResultsA total of 994 patients were included, 166 were with ALL, 828 with ANLL, there were 181 pairs of case group and control group, and 15 pairs of ALL group and ANLL group. Direct economic losses in ALL group and ANLL group were 13 089.0 ￥ and 21 565.0 ￥ respectively ; extension of length of hospital stay due to HAI were 10.5 and 10.0 days respectively, differences were statistically significant between case group and control group (both P<0.05). The total hospitalization expense, as well as fees for bed, consultation, treatment, laboratory examination, nursing, medicine, traditional Chinese medicine, and blood transfusion in ANLL group were all higher than ALL group, but there were no significant difference.ConclusionHAI in patients with AL can increase hospitalization cost and prolong length of hospital stay.