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Clinical efficacy of Huaiqihuang granule in the treatment of children with bronchial asthma and its effects on the level of cytokines Th1, Th2 and PON1

??Objective??To observe the clinical efficacy of Huaiqihuang in the treatment of children with bronchial asthma and its effects on the level of cytokines Th1??Th2 and PON1. Methods??A total of 180 children with bronchial asthma admitted between June 2014 and June 2015 in the Fourth Hospital of Baotou were randomized into the observation group??96 cases of GINA regimen treatment combined with Huaiqihuang??and the GINA regimen treatment group??84 cases????healthy children were enrolled as control group??50 cases??. Times of respiratory tract infection occurrence, asthmatic attacks, application of emergency medicine, hospitalization due to asthmatic and the levels of IL-4??IL-12??IL-13??INF-γ and PON1 were observed before and after treatment. Results??There were significant differences about the times of upper respiratory tract infections, bronchitis and pneumonia, asthma attacks, application of emergency medicine and hospitalization due to asthmatic??P??0.05??. There were significant differences about the changes of IL-4, IL-12, IL-13, INF-γ and PON1 before and after treatment??P??0.01??. Conclusion??The treatment of bronchial asthma in children with Huaiqihuang granule can reduce the incidence of respiratory infections and the number of asthmatic attacks and improve clinical effect. The Huaiqihuang granule alleviating asthma symptoms may by decreasing the levels of Th2 cytokines??IL-4??IL-13??and also by increasing the levels of Th1 cytokines??IL-12, IFN-γ??and PON1.