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Application of 24-hour gastric and esophageal double pH monitoring in neonatal gastroesophageal reflux diseases

??The 24-hour intraesophageal pH monitoring is a widely used method in diagnosis of gastroesophageal reflux diseases. It has been regarded as the diagnositic standard of these diseases. Due to the technical limitation?? the traditional pH monitoring can only show the acid refluxes in the lower esophagus instead of the mixed and alkaline ones. As a result?? there is inevitably a proportional rate of misdiagnosis in the traditional pH monitoring. The 24-hour gastric and esophageal double pH monitoring can perfectly solve this problem. In this method?? both the gastric and esophageal pH is recorded for 24 hours. Both the acid refluxes in the lower esophagus and the duodenogastric reflux and the mixed and alkaline refluxes can be clearly demonstrated. With improvement of accuracy?? the 24-hour gastric and esophageal double pH monitoring has been used in adults and adolescent?? but rarely in the neonates. In this paper??the key point of this method and its application in neonates and prematures was reviewed and introduced.