| 表皮生长因子受体在鼠角膜损伤前后的表达 |
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| 引用本文： | 熊新春,魏厚仁,杜蜀华,郝连杰.表皮生长因子受体在鼠角膜损伤前后的表达[J].华中科技大学学报(医学版),1998(5). |
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| 作者姓名： | 熊新春 魏厚仁 杜蜀华 郝连杰 |
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| 作者单位： | 同济医科大学附属协和医院眼科 武汉430022(熊新春，魏厚仁)，同济医科大学附属同济医院眼科 武汉430030(杜蜀华)，同济医科大学附属同济医院临床免疫学研究室 武汉430030(郝连杰) |
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| 摘 要： | 采用免疫组织化学PAP法检测正常及刮除部分角膜上皮3、6、12、24h后大鼠角膜内表皮生长因子受体(Epidermal Growth Factor Receptor,EGFR)的分布。结果:正常状态下,只有角膜缘干细胞和近前弹力层角膜上皮细胞表达EGFR。角膜上皮缺损后6h,损伤区角膜上皮均表达EGFR。当损伤后24h,角膜上皮缺损恢复时,在基质层内可见EGFR阳性基质细胞。结果表明:表达EGFR的角膜上皮细胞具有很强的增殖能力,在角膜损伤修复中起重要作用。
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| 关 键 词： | 表皮生长因子受体 角膜 |
The Expression of Epidermal Growth Factor Receptor before and after the Removal of Rat Corneal Epithelial |
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| Xiong Xinchun',Wei Houren'.Du Shuhua et al'.The Expression of Epidermal Growth Factor Receptor before and after the Removal of Rat Corneal Epithelial[J].Journal of Huazhong University of Science and Technology(Health Sciences),1998(5). |
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| Authors: | Xiong Xinchun' Wei Houren'Du Shuhua ' |
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| Institution: | Xiong Xinchun',Wei Houren'.Du Shuhua2 et al' Department of Ophthalmology,Xiehe Hospital,Tongji Medical University,Wuhan 430022 'Department of Ophthalmology,Tongji Hospital,Tongji Medical University,Wuhan 430030 |
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| Abstract: | The expression of epidermal growth factor receptor (EGFR) in corneal epithelial in normal rats and the rats 3,6,12,24 h after the partial removal of corneal epithelial was determined by using immuno-histochemical PAP method. Only the epithelial near the limbus and the Bowman's membrane showed strong expression of EGFR in normal cornea. The epithelial near the wound exposed to tears for 6 h after injury ex-pressed EGFR. 24 h later,some EGFR-positive cells in the stroma were found after recovery of corneal ep-ithelial. It was concluded that the corneal epithelial expressing EGFR had a good proliferating ability and play an important role in the cornea repair after injury. |
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| Keywords: | epidermal growth factor receptor cornea |
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