精神分裂症患者及其一级亲属探究性眼球轨迹运动的研究

目的 探讨精神分裂症患者及其一级亲属的眼球轨迹运动在生物遗传学上的意义。方法 应用眼球轨迹运动标记记录仪，对６４例精神分裂症患者（症状显著２６例，症状缓解３８例）及其２６例一级亲属、３５名正常人进行测试。经判别式分析获正分者为精神分裂症性障碍，获负分者为非精神分裂症性障碍，并以眼球轨迹运动的有关参数作分析指标。结果 显著组患者判别式分析平均获２．０７６分，缓解组患者获２．５７１分，一级亲属且平均获

Tracks of explorative eye movements in schizophrenics and their first rank relatives

Objective To compare the differences of eye movements between schizophrenics, their first relatives and normal control. Methods 64 schizophrenics (including 26 with prominent symptoms and 38 in relief), 26 their first rank relatives and 35 normal controls were test by Eye Movement Tracker Model IV. According to Discriminate analysis, the subjects were divided into positive score group (schizophrenics disorder group ) and negative score group (non schizophrenics group). Results Discriminant analysis suggested: the average scores were 2.076, 2.571, 2.677 and 0.267 in schizophrenics with prominent symptoms, schizophrenics in relief, the relatives of schizophrenics and normal controls, respectively. There was no difference in Number of Eye Fixation, Cognitive of Search Score, Total of Eye Scanning Length, Mean Eye Scanning Length (MESL)and Responsive of Search score in schizophrenics with or without prominent symptoms. No difference was noted in all these parameters between schizophrenics and their first rank relatives. However, there were significantly different in these parameters between schizophrenics or their first rank relatives and normal controls ( P <0.05). Conclusion Tracks of eye movements are abnormal in schizophrenics and their first rank relatives, suggesting that the abnormal eye movements may be a genetic marker of schizophrenia.