皮肤T细胞淋巴瘤表观遗传学研究进展 |
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引用本文: | 王小坡,孙建方. 皮肤T细胞淋巴瘤表观遗传学研究进展[J]. 国际皮肤性病学杂志, 2016, 0(1): 11-14. DOI: 10.3760/cma.j.issn.1673-4173.2016.01.004 |
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作者姓名: | 王小坡 孙建方 |
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作者单位: | 中国医学科学院北京协和医学院皮肤病研究所病理科,南京,210042 |
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基金项目: | 江苏省临床医学科技专项基金 |
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摘 要: | 表观遗传学主要是研究在不改变DNA序列的情况下,发生的基因表达水平可遗传的变化,主要包括DNA甲基化、组蛋白修饰和非编码RNA调控.皮肤T细胞淋巴瘤是一组原发于皮肤的T淋巴细胞恶性增殖性疾病,蕈样肉芽肿和Sezary综合征是最常见的皮肤T细胞淋巴瘤.近年来研究表明,表观遗传学不仅在皮肤T细胞淋巴瘤的发生发展中起重要作用,而且可以通过改变表观遗传达到治疗皮肤T细胞淋巴瘤目的.
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关 键 词: | 淋巴瘤,T细胞,皮肤 后成说,遗传 蕈样肉芽肿 Sezary综合征 DNA甲基化 |
Epigenetics in cutaneous T-cell lymphoma |
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Abstract: | Epigenetics means heritable changes in gene expressions without alterations in DNA sequence, and mainly involves DNA methylation, histone modification and non-coding RNA regulation.Cutaneous T-cell lymphoma is a class of malignant T-cell lymphoproliferative diseases originated from the skin.Mycosis fungoides and Sezary syndrome are the most common cutaneous T-cell lymphoma.Recent studies have shown that epigenetics not only plays an important role in the occurrence and development of cutaneous T-cell lymphoma, but also provides insights into the treatment of cutaneous T-cell lymphoma. |
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Keywords: | Lymphoma,T-cell,cutaneous Epigenesis,genetic Mycosis fungoides Sezary syndrome DNA methylation |
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