凝血机制参与慢性荨麻疹发病的研究进展

凝血机制与慢性荨麻疹有关.内外凝血途径均参与其发病,同时被激活产生凝血酶.凝血酶不仅可以直接作用于血管内皮细胞,增加血管通透性,还可以间接使肥大细胞脱颗粒释放组胺,从而诱发荨麻疹.慢性荨麻疹患者检测出的一些凝血标记物也间接证明凝血机制参与其发病.在慢性荨麻疹发病过程中,凝血机制与炎症反应机制、自身免疫机制和血管机制密切相关.对于抗组胺治疗无效的顽固性荨麻疹患者,抗凝血治疗提供了新的思路和方向.

Coagulation mechanisms are involved in the pathogenesis of chronic urticaria: an update

Recent studies have suggested that coagulation mechanisms are associated with chronic urticaria.Both the intrinsic and extrinsic pathways of blood coagulation are involved in the pathogenesis of chronic urticaria, which are activated simultaneously followed by the generation of thrombin.Thrombin can not only directly act on vascular endothelial cells and increase vascular permeability, but also can indirectly induce mast cells to degranulate and release histamine, and then cause the development of urticaria.Some coagulation markers have been found in patients with chronic urticaria, which indirectly suggests the involvement of coagulation mechanisms in the pathogenesis of chronic urticaria.In the development of chronic urticaria, coagulation mechanisms are closely related to inflammatory response mechanisms, autoimmune mechanisms and vascular mechanisms.Anti-coagulation treatments have provided new ideas and directions for the treatment of intractable urticaria unresponsive to antihistamines.