益气逐瘀颗粒的主要药效学研究

目的验证益气逐瘀颗粒的主要药理作用.方法以注射肾上腺素及冰水游泳建立大鼠急性血瘀证模型,观察益气逐瘀颗粒对急性血瘀模型大鼠血液流变学指标的影响;以舌下静脉注射垂体后叶素建立大鼠心肌缺血模型,观察该制剂对心肌缺血模型动物ST-T段位移变化和对肌酸激酶(CK)、乳酸脱氢酶(LDH-L)含量的影响;以二磷酸腺苷(ADP)为诱导剂,进行血小板聚集活性测定.结果益气逐瘀颗粒对血瘀证有一定的改善作用,能降低全血黏度,对血浆黏度未见明显影响;能够缓解垂体后叶素引起的大鼠急性心肌缺血,减轻S-T段抬高程度;降低LDH-L的活性,可明显抑制ADP诱导的大鼠血小板聚集.结论益气逐瘀颗粒对急性血瘀模型大鼠血液流变学指标有一定的改善作用,抑制血小板聚集,对大鼠实验性急性心肌缺血有一定的保护作用.

The Experimental Study on Pharmacodynamics of Yiqi Zhuyu Granule

Objective:To verify the main pharmacological action of Yiqi Zhuyu granule. Methods:The acute syndrome of blood stasis models of rat were set up by injecting Adr and swimming in ice water in order to observe the hemorheology of rat. The acute myocardial ischemia models of rat were set up by injecting hypophysin. The electrocardiogram was recorded, CK and LDH-L was determined. Using ADP as inductor to measure the degree of platelet aggregation. Results: Yiqi Zhuyu granule could alleviate the damages caused by acute syndrome of blood stasis and acute myocardial ischemia, and it could cut down whole blood viscosity, but there was no significant influence about plasma viscosity. It could cut down the activity of LDH-L, and it could obviously hold back platelet aggregation of rat caused by ADP inductor. Conclusions: Yiqi Zhuyu granule could improve the changes of acute syndrome of blood stasis and alleviate the damages caused by acute myocardial ischemia, and it also could obviously hold back platelet aggregation. All these results prove that it could promoting blood flow.