Platelet function and coagulation in normal and preeclamptic pregnancy |
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| Authors: | F Pekonen V Rasi M Amm?l? L Viinikka O Ylikorkala |
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| Institution: | 1. Department of Medicine I, Medical University of Vienna, Vienna, Austria;2. Karl Landsteiner Institute of Clinical Thrombosis Research, Vienna, Austria;3. Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria;1. Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria;2. Clinical Institute of Medical and Chemical Laboratory Diagnostic, Medical University of Vienna, Vienna, Austria;3. Division of Haematology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria;1. Kidney Therapeutic Center of Traditional Chinese and Western Medicine, Beidaihe Sanatorium of Beijing Military Region, Qinhuangdao, China;2. Hemodialysis Centre, Beidaihe Sanatorium of Beijing Military Region, Qinhuangdao, China;3. Hemodialysis Centre, First Affiliated Hospital of Haerbin Medical University, Haerbin, China;4. Hemodialysis Centre, General Hospital of Beijing Military Region, Beijing, China;1. Department of Electrocardiology, The John Paul II Hospital, 80 Pradnicka St., 31-202 Kraków, Poland;2. Translational Medicine Laboratory, Department of Internal and Agricultural Medicine, Jagiellonian University Medical College, 1 Skarbowa St., 31-121 Kraków, Poland;3. The J. Dietl Specialist Hospital, 4 Skarbowa St., 31-121 Kraków, Poland;4. Department of Cardiology, Pomeranian Medical University, 72 Powstańców Wlkp. St., 70–111 Szczecin, Poland;5. Institute of Cardiology, Jagiellonian University Medical College, 80 Pradnicka St., 31-202 Kraków, Poland |
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| Abstract: | Platelet function and coagulation activity were followed prospectively throughout normal pregnancy and in puerperium in 17 healthy women. Plasma beta-thromboglobulin reflecting platelet activation increased progressively during pregnancy. This was not accompanied by any changes in platelet count or lifespan nor in serum or plasma thromboxane B2 levels. The levels of both factor VIII:C and factor VIIIR:Ag increased, the former less than the latter resulting in a rise of the FVIIIR:Ag/FVIII:C ratio. Antithrombin III (AT III), however remained unaltered. FVIIIR:Ag/FVIII:C ratio was increased both in mild (n = 7) and severe (n = 9) preeclampsia, whereas beta-thromboglobulin was increased and AT III was decreased only in severe preeclampsia. Platelet count and lifespan, plasma and serum thromboxane B2 as well as FVIII:C were normal in severe preeclampsia. |
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