| 肺嗜酸细胞类癌2例病理学观察 |
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| 引用本文： | 陆鸣,陈书媛,宋红梅,张长淮.肺嗜酸细胞类癌2例病理学观察[J].诊断病理学杂志,2002,9(2):77-78. |
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| 作者姓名： | 陆鸣 陈书媛 宋红梅 张长淮 |
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| 作者单位： | 1. 首都医科大学附属北京友谊医院病理科,北京,100050
2. 北京丰台铁路分局中心医院病理科 |
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| 摘 要： | 目的 探讨肺嗜酸细胞类癌的病理学特点及鉴别诊断。方法 对2例肺嗜酸细胞类癌的组织病理学、免疫组织化学及电镜结果进行观察分析。结果 2例肺嗜酸细胞类癌的组织病理学特点：瘤细胞胞质内有多量嗜酸性细颗粒。免疫组化：角蛋白、NSE、CgA、Syn呈阳性表达，S－100呈阴性表达。电镜：瘤细胞胞质内见多量神经内分泌颗粒和增多的线粒体。结论 肺嗜酸细胞类癌具独特的病理学特点，免疫组化和电镜结果有助于鉴别诊断。
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| 关 键 词： | 肺肿瘤 肺嗜酸细胞类癌 病理学 免疫组化 鉴别诊断 肺癌 |
| 文章编号： | 1007-8096(2002)02-0077-02 |
| 修稿时间： | 2001年9月7日 |
Oncocytic carcinoid rumor of the lung: a report of two cases with review of the literature |
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| Lu Ming,Chen Shuyuan,Song Hongmei,et al..Oncocytic carcinoid rumor of the lung: a report of two cases with review of the literature[J].Chinese Journal of Diagnostic Pathology,2002,9(2):77-78. |
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| Authors: | Lu Ming Chen Shuyuan Song Hongmei |
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| Institution: | Lu Ming,Chen Shuyuan,Song Hongmei,et al. Department of Pathology,Beijing Friendship Hospital,the Capital University of Medical Sciences,Beijing 100050 |
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| Abstract: | Objective To investigate the pathologic features of oncocytic carcinoid tumor of the lung (OCTL) and its diagnosis. Methods Histopathologic changes, immunohistochemical findings and ultrastructural alterations were analyzed in 2 cases. Results The tumor cells had abundent finely granular eosinophilic cytoplasm. Immunohistochemical staining showed the tumor cells were positive for chromogranin A, NSE, synaptophysin and cytokeratins, and negative for S 100 protein. Ultrastructural findings were that the tumor cell cytoplasm contained abundent dense core neurosecretory granules and abundent mitochondria. Conclusions OCTL is a morphologically distinctive entity of disease. It can be differentiated from other pulmonary tumors based on immunohistochemical staining and ultrastructural examination. < |
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| Keywords: | Lung neoplasm Oncocytic carcinoid Histopathology |
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