番石榴叶对诺瓦克样病毒性腹泻患儿唾液中IFN-γ、IL-2水平的影响

目的了解番石榴叶对诺瓦克样病毒（NVs）腹泻患儿唾液中干扰素-γ（IFN-γ）、白介素-2（IL-2）的调节作用。方法将50例NVs腹泻患儿随机分为番石榴叶治疗组（治疗组A，30例）和思密达治疗组（治疗组B，20例），并随机抽取20名健康儿童作为正常对照组。采用ELISA法对3组治疗前及治疗组A、B治疗后唾液中IFN-γ、IL-2进行测定。结果治疗前NVs腹泻患者IFN—γ、IL-2明显高于正常对照组（P〈0．01）。治疗后治疗组AIFN—Y、IL-2明显升高，治疗组B升高不明显，治疗组A优于治疗组B（P〈0．01）。结论NVs腹泻患者IFN—γ、IL-2水平较正常人明显增高；番石榴叶能够提高NVs腹泻患者唾液中IFN-γ、IL-2水平，调节细胞免疫功能，促进Th1细胞免疫的作用。

Effect of Guava Leaf on IFN-γ and IL-2 in Salivary of Children Patients with Noroviruses Diarrhea

Objective To elucidate the regulate role of the guava leaf on the levels of IFN-γ and IL-2 in the salivary juice on children patients with noroviruses diarrhea. Method 50 patients with noroviruses diarrhea was grouped randomly to group A /30 patients）, which was treated with guava leaf and group B /20 patients）, which was treated with Smecta, and 20 health children was randomly choiced as normal control group. The levels of IFN-γ and IL-2 in the salivary juice of the three groups were determined and compared before and after the treatments. Results The levels of IFN-γ and IL-2 in the group A and B before the treatments were higher than the normal control group （P〈0.01）, the levels of IFN-γ and IL-2 before the treatment in group A were higher than that after the treatment, the group B had no much change after the treatment. The levels of IFN-γ and IL-2 in the group A were higher than the group B after the treatments. Conclusion The levels of IFN-γ and IL-2 in the salivary juice in the patients with noroviruses diarrhea were higher than the normal health patients. Guava leaf has the effect of raising the levels of IFN-γ and IL-2 in the salivary juice on noroviruses diarrhea patients, so it can regulate the cellular immune function and promote the T helper cell 1 （Th 1） immunity.