| 兔颈动脉损伤后再狭窄与p53蛋白关系的研究 |
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| 引用本文： | 蒋伟,王书梅,顾新元,唐良秋.兔颈动脉损伤后再狭窄与p53蛋白关系的研究[J].中国医师杂志,2010,13(11):300-301,327. |
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| 作者姓名： | 蒋伟 王书梅 顾新元 唐良秋 |
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| 作者单位： | 韶关市粤北人民医院心内科,广东省韶关,512025;韶关市粤北人民医院口腔科,广东省韶关,512025; |
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| 基金项目： | 广东省韶关市科技局计划项目 |
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| 摘 要： | Objective To observe the effect of p53 protein on smooth muscle cell(VSMC)in rabbit artery balloon injury.Methods Restenosis model of carotid artery after balloon injury was established in rabbits.30 rabbits were divided into 2 groups,the sham group(n = 6)and the vascular injury group(n = 24).With H.E.staining and automatic image analysis system,we investigated artery morphology alteration and measured the area of arterial intima and media.The expressions of p53 protein were detected by immunohistochemical analysis.Results With H.E.staining and automatic image analysis and immunohistochemistry,the results showed that the expression of p53 was significantly reduced and the intima area was increased in model group compared with the sham group(P ＜0.01).But the expression of p53 in media was remarkably reduced compared with intima(P ＜ 0.01).Conclusions The possible mechanism of preventing arterial restenosis in the balloon injury might be related with p53,which may be through inhibiting neointimal proliferation in arterial restenosis .
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| 关 键 词： | 肿瘤抑制蛋白质p53/代谢 颈动脉损伤/并发症/代谢 缩窄 病理性/并发症/代谢 血管成形术 经腔 经皮冠状动脉/副作用 |
The expression of p53 in preventing restenosis after rabbit carotid artery balloon injury |
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| JIANG Wei,WANG Shu-mei,GU Xin-yuan,TANG Liang-qiu.The expression of p53 in preventing restenosis after rabbit carotid artery balloon injury[J].Journal of Chinese Physician,2010,13(11):300-301,327. |
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| Authors: | JIANG Wei WANG Shu-mei GU Xin-yuan TANG Liang-qiu |
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| Abstract: | |
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| Keywords: | Tumor suppressor protein p53/MECarotid artery injuries/CO/MEConstriction pathologic/CO/MEAngioplasty transluminal percutaneous coronary/AE |
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